20410-95-1 Usage
Description
6 alpha-naloxol, also known as 6α-naloxol, is a natural chemical compound that functions as an opioid antagonist. It is an active metabolite of the opioid drug naloxone and is also produced in the human body as a metabolite of endogenous opioids. 6 alpha-naloxol operates by binding to the same brain receptors as opioids, yet it does not elicit the same effects. It is considered to have potential therapeutic applications in treating opioid addiction and overdose, as well as in modulating pain and stress responses within the body. Ongoing research is exploring the effects and uses of 6 alpha-naloxol, making it a topic of interest in pharmacology and medicine.
Uses
Used in Pharmaceutical Industry:
6 alpha-naloxol is used as a therapeutic agent for the treatment of opioid addiction due to its antagonistic properties that can help mitigate withdrawal symptoms and cravings associated with opioid dependence.
Used in Emergency Medicine:
6 alpha-naloxol is used as an antidote in cases of opioid overdose, as it can rapidly reverse the effects of opioids, thereby preventing respiratory depression and other life-threatening complications.
Used in Pain Management:
6 alpha-naloxol is used as an analgesic agent to regulate pain responses in the body, offering a potential alternative to traditional opioids for managing chronic pain without the risk of addiction.
Used in Stress Response Regulation:
6 alpha-naloxol is used as a modulator of the body's stress response, potentially providing a means to alleviate stress-related symptoms and promote overall well-being.
The applications of 6 alpha-naloxol are diverse and span across various medical fields, highlighting its potential as a valuable compound in addressing a range of health issues related to opioid use and stress management.
Check Digit Verification of cas no
The CAS Registry Mumber 20410-95-1 includes 8 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 5 digits, 2,0,4,1 and 0 respectively; the second part has 2 digits, 9 and 5 respectively.
Calculate Digit Verification of CAS Registry Number 20410-95:
(7*2)+(6*0)+(5*4)+(4*1)+(3*0)+(2*9)+(1*5)=61
61 % 10 = 1
So 20410-95-1 is a valid CAS Registry Number.
InChI:InChI=1/C19H23NO4/c1-2-8-20-9-7-18-15-11-3-4-12(21)16(15)24-17(18)13(22)5-6-19(18,23)14(20)10-11/h2-4,13-14,17,21-23H,1,5-10H2/t13-,14+,17-,18-,19+/m0/s1
20410-95-1Relevant articles and documents
Ring C conformation of 6beta-naltrexol and 6alpha-naltrexol. Evidence from proton and carbon-13 nuclear magnetic resonance.
Brine,Praskash,Hart,Kotchmar,Moreland,Carroll
, p. 3445 - 3448 (1976)
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PROCESS FOR MAKING MORPHINAN-6alpha-OLS
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Page/Page column 7, (2010/03/02)
The present invention provides a process whereby morphinan-6-ones can be converted stereospecifically to the corresponding morphinan-6α-ols by catalytic hydrogenation under basic conditions.
Morphine Alkaloids, Part 114 A. Stereohomogeneous Synthesis of N-Demethyl-N-Substituted-14-Hydroxydihydromorphines
Hosztafi, Sandor,Berenyi, Sandor,Toth, Geza,Makleit, Sandor
, p. 435 - 442 (2007/10/02)
A new route for the stereohomogeneous synthesis of N-demethyl-N-substituted-14-hydroxydihydromorphines 2a-f has been elaborated, involving O-demethylation of the novel dihydrocodeine derivatives 6a-f, obtained upon alkylation of the hitherto unknown N-demethyl-14-hydroxydihydrocodeine (5). Keywords. 6α,14β-Diacetoxy-4,5α-epoxy-3-methoxy-17-methyl-morphinan, N-demethylation of; 3,6α,14β-Triacetoxy-17-alkyl-4,5α-epoxymorphinan, N-demethylation of; 17-Alkyl-4,5α-epoxy-6α,14β-dihydroxy-3-methoxymorphinan, O-demethylation of; 4,5α-Epoxy-6α,14β-dihydroxy-3-methoxymorphinan, N-alkylation of.
