20423-99-8Relevant articles and documents
Preparation method of deprodone propionate
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Paragraph 0015; 0020; 0025, (2018/04/01)
The invention relates to a preparation method of deprodone propionate. The preparation method comprises the following steps: dissolving a mildew extract with a relatively price, as a raw material, into an organic solvent, adding pyridine, and introducing sulfur trioxide to dehydrate 11-site a hydroxyl, so as to obtain a dehydrated object; dissolving the dehydrated object into the organic solvent to epoxidize a 11-site double bond under the catalysis of caustic soda, so as to obtain an epoxidized object; dissolving the epoxidized object into the organic solvent to generate reaction by virtue ofa double epoxy bond with hydrobromic acid under the catalysis of acetic anhydride, so as to obtain dibromide; carrying out reduction debromination on dibromide molecules, so as to obtain deprodone; and finally carrying out propionylation on deprodone, so as to obtain deprodone propionate. The total yield by weight of the above five steps is 60-65%, and the HPLC content of the final product is 99.0% or above. The preparation method has the beneficial effects that a synthetic route is reasonable in design, the production raw materials are cheap and easily available, the process operation is simple and environmentally friendly, the total yield is high, the product quality is good, and the production cost is 20%-25% lower than a traditional method; and furthermore, the reaction solvent can berecycled and circularly used, so that the method is economic, environmentally friendly and very suitable for industrial production.
Synthesis of the 16α,17α,21-trimethyl corticosteroid rimexolone from prednisolone
Conrow, Raymond E.
, p. 1042 - 1044 (2007/10/03)
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