2044-27-1

Basic information

• Product Name: 1-methylpyridine-2-thione
• Synonyms: 1-methylpyridine-2-thione;1-Methyl-1,2-dihydropyridine-2-thione;1-Methyl-2(1H)-pyridinethione
• CAS NO: 2044-27-1
• Molecular Formula: C₆H₇NS
• Molecular Weight: 125.19
• Mol File: 2044-27-1.mol
• Article Data: 3

Chemical Properties

• Boiling Point: 187.6 °C at 760 mmHg
• Flash Point: 67.2 °C
• Appearance: /
• Density: 1.16 g/cm³
• Vapor Pressure: 0.626mmHg at 25°C
• Refractive Index: 1.636
• CAS DataBase Reference: 1-methylpyridine-2-thione(CAS DataBase Reference)
• NIST Chemistry Reference: 1-methylpyridine-2-thione(2044-27-1)
• EPA Substance Registry System: 1-methylpyridine-2-thione(2044-27-1)

Safety Data

• Hazardous Substances Data: 2044-27-1(Hazardous Substances Data)

Usage

General Description

1-Methylpyridine-2-thione, also known as 2-pyridinethiol, is a chemical compound with the molecular formula C6H7NS. It is a yellow to reddish-brown liquid with a strong, unpleasant odor. 1-Methylpyridine-2-thione is commonly used in the pharmaceutical and agricultural industries as a building block for the synthesis of various pharmaceuticals and agrochemicals. It has also been studied for its potential use as a corrosion inhibitor and as a precursor for the synthesis of metal complexes. Additionally, it has been investigated for its potential biological activities, including its antimicrobial, antifungal, and antioxidant properties. However, caution should be exercised when handling 1-methylpyridine-2-thione because it is toxic if ingested, inhaled, or in contact with skin.

InChI:InChI=1/C6H7NS/c1-7-5-3-2-4-6(7)8/h2-5H,1H3

Upstream product

• 90-04-0 2-methoxy-phenylamine 
• 534-18-9 sodium trithiocarbonate 
• 75-64-9 tert-butylamine 
• 109-73-9 N-butylamine 
• 87-62-7 2,6-dimethylaniline 
• 100-46-9 benzylamine 
• 95-53-4 o-toluidine 
• 95-54-5 1,2-diamino-benzene 
• 62-53-3 aniline 
• 107-15-3 ethylenediamine 
• 75-31-0 isopropylamine 
• 63434-91-3 2-(methyldisulfanyl)pyridine 
• 108-98-5 thiophenol 
• 104-94-9 4-methoxy-aniline 

Downstream Products

• 77148-44-8 C₁₂H₁₃N₂S⁽¹⁺⁾*ClH*Cl^(1-) 
• 77148-46-0 C₁₂H₁₃N₂S⁽¹⁺⁾*ClH*Cl^(1-) 
• 859845-73-1 6-allyl-1-methyl-3,6-dihydro-1H-pyridine-2-thione 
• 478620-27-8 2[[(2,5-dimethylphenyl)methyl]thio]-1-methylpyridinium chloride 
• 62058-66-6 1-Methyl-2-(2-phenylethylthio)-pyridinium bromide 
• 77148-85-7 1-Methyl-2-((3-methylbenzyl)thio)pyridinium chloride 
• 14210-70-9 3-benzoyloxy-4,5-bis-benzoyloxymethyl-2-methyl-pyridine 
• 694-85-9 1-methyl-2-pyridone 
• 87577-79-5 C₂₀H₂₂N₂S₂⁽²⁺⁾*2Br^(1-) 
• 77148-79-9 2-((-4-Isopropylbenzyl)thio)-1-methylpyridinium chloride 
• 77148-75-5 2-(((4-Benzyloxy)benzyl)thio)-1-methylpyridinium chloride 
• 77155-91-0 1-Methyl-2-((3-trifluoromethylbenzyl)thio)pyridinium chloride 
• 77148-68-6 1-Methyl-2-(4-nitrobenzylthio)pyridinium bromide 
• 77148-91-5 1-Methyl-2-((3-nitro)benzylthio)pyridinium chloride 

Relevant articles and documents

A New Procedure for the Conversion of Thiols into Reactive Sulfenylating Agents

Thiols may be converted in high yield into unsymmetrical 2-pyridyl disulfides 3.Treatment of these with alkylating agents (e.g., alkyl fluorosulfonates or oxonium salts) affords the corresponding N-alkylpyridyl disulfides 4, which are potent sulfenylating agents (Scheme II) and react smoothly with a variety of sulfur nucleophiles (e.g., thiols, thiones, thioamides, dithiocarbamates, thiocyanate, etc.) to afford disulfides, with amines to afford sulfenamides, and with β-diketones to afford sulfides.This new method is particularly well-suited to the preparation of unsymmetrical disulfides and sulfenamides from complex and otherwise r eactive thiols.

A CONVENIENT METHOD FOR THE PREPARATION OF N,N'-DISUBSTITUTED THIOUREAS USING 2-CHLOROPYRIDINIUM SALT, SODIUM TRITHIOCARBONATE AND AMINES

N,N'-Disubstituted thioureas were prepared in high yields by treating 2-chloropyridinium salt with sodium trithiocarbonate and subsequently adding amines.