2045-19-4

Basic information

• Product Name: N,N-BIS[2-BROMO-ETHYL]ANILINE
• Synonyms: N,N-BIS[2-BROMO-ETHYL]ANILINE
• CAS NO: 2045-19-4
• Molecular Formula: C₁₀H₁₃Br₂N
• Molecular Weight: 307.06
• Mol File: 2045-19-4.mol
• Article Data: 6

Chemical Properties

• Melting Point: 52-53 °C(Solv: methanol (67-56-1))
• Boiling Point: 332.2°C at 760 mmHg
• Flash Point: 154.7°C
• Appearance: /
• Density: 1.6367 (rough estimate)
• Vapor Pressure: 0.000148mmHg at 25°C
• Refractive Index: 1.6300 (estimate)
• PKA: 4.35±0.50(Predicted)
• CAS DataBase Reference: N,N-BIS[2-BROMO-ETHYL]ANILINE(CAS DataBase Reference)
• NIST Chemistry Reference: N,N-BIS[2-BROMO-ETHYL]ANILINE(2045-19-4)
• EPA Substance Registry System: N,N-BIS[2-BROMO-ETHYL]ANILINE(2045-19-4)

Safety Data

• Hazardous Substances Data: 2045-19-4(Hazardous Substances Data)

Usage

InChI:InChI=1/C10H13Br2N/c11-6-8-13(9-7-12)10-4-2-1-3-5-10/h1-5H,6-9H2

Upstream product

• 120-07-0 2,2'-(phenylimino)bis[ethanol] 
• 124-38-9 carbon dioxide 
• 106-93-4 ethylene dibromide 
• 62-53-3 aniline 
• 92-53-5 4-Phenylmorpholine 
• 22964-38-1 N,N-bis<2-<(methylsulfonyl)oxy>ethyl>aniline 

Downstream Products

• 240797-81-3 10-phenyl-1,4-dioxa-7,13-dithia-10-aza-cyclopentadecane 
• 4096-21-3 N-phenylpyrrolidine 
• 141547-34-4 N,N-bis(2-(diphenylphosphanyl)ethyl)phenylamine 
• 109602-92-8 N,N-bis-(2-bromo-ethyl)-4-(2,4-dinitro-phenyldisulfanyl)-aniline 
• 64977-21-5 N,N-bis-(2-bromo-ethyl)-4-carbamoylsulfanyl-aniline 
• 99857-68-8 N,N-bis-(2-bromo-ethyl)-4-methylsulfanyl-aniline 
• 94804-47-4 bis-{4-[bis-(2-bromo-ethyl)-amino]-phenyl}-disulfide 
• 64977-19-1 4-[bis-(2-bromo-ethyl)-amino]-thiophenol 

Relevant articles and documents

The bivalent ligand approach as a tool for improving the in vitro anti-alzheimer multitarget profile of dimebon

Inspired by the concept of bivalent ligands, we prepared a small set of analogues of the drug candidate dimebon. They were shown to inhibit AChE, Aβ42 aggregation, and NMDA receptor activation to a greater extent than dimebon. Some of these compounds also enhanced the survival of chicken neurons under apoptosis-inducing conditions. Copyright

Synergetic activation of CO2by the DBU-organocatalyst and amine substrates towards stable carbamate salts for synthesis of oxazolidinones

The development of an efficient methodology to transform CO2 into valuable chemicals has attracted increasing attention concerning the challenging issues of CO2-utilization. Herein, an efficient approach for the preparation of oxazolidinones from CO2, primary (aliphatic/aromatic) amines and 1,2-dichloroethane (or its derivatives) catalyzed by DBU organo-superbase was achieved with yields of 47-97% under mild conditions (80-100 °C, 12 h, 1.0 MPa CO2). Control experiments demonstrated that the formation of an ion-pair carbamate salt intermediate IS-B derived from the reaction of CO2, DBU (catalyst) and an amine (substrate) was the key step for this three-component reaction. The available DBU-amine-CO2 adduct intermediate (like IS-B-2) with fair stability will evolve into the thermodynamically stable product oxazolidinones upon attack of 1,2-dichloroethane (or its derivatives), along with the regeneration of the DBU catalyst. Alternatively, the decomposition of the DBU-aryl amine-CO2 adduct (like IS-B-1) with relatively poor stability also could result in the competitive substitution reaction of 1,2-dichloroethane (or its derivatives) with the aryl amine. This work provides insights into synergetic CO2-activation by the DBU-catalyst and a nucleophilic amine-substrate via the formation of robust carbamate salt intermediates responsible for the final production of oxazolidinones. This journal is

A near IR di-styryl BODIPY-based ratiometric fluorescent chemosensor for Hg(II)

A novel BODIPY-based near-IR emitting probe as a selective and sensitive fluorophore for Hg(II) is synthesized. This versatile BODIPY fluorophore is functionalized for long wavelength emission at the 3 and 5 positions via a condensation reaction in which