2045-39-8

Basic information

• Product Name: Acetamide, N-(3-fluoro-4-hydroxyphenyl)-
• Synonyms: Acetamide, N-(3-fluoro-4-hydroxyphenyl)-
• CAS NO: 2045-39-8
• Molecular Formula: C₈H₈FNO₂
• Molecular Weight: 169.15
• Mol File: 2045-39-8.mol
• Article Data: 8

Chemical Properties

• Boiling Point: 351.8°Cat760mmHg
• Flash Point: 166.6°C
• Appearance: /
• Density: 1.351g/cm³
• Vapor Pressure: 1.97E-05mmHg at 25°C
• Refractive Index: 1.592
• CAS DataBase Reference: Acetamide, N-(3-fluoro-4-hydroxyphenyl)-(CAS DataBase Reference)
• NIST Chemistry Reference: Acetamide, N-(3-fluoro-4-hydroxyphenyl)-(2045-39-8)
• EPA Substance Registry System: Acetamide, N-(3-fluoro-4-hydroxyphenyl)-(2045-39-8)

Safety Data

• Hazardous Substances Data: 2045-39-8(Hazardous Substances Data)

Usage

InChI:InChI=1/C8H8FNO2/c1-5(11)10-6-2-3-8(12)7(9)4-6/h2-4,12H,1H3,(H,10,11)

Upstream product

• 446-31-1 2-fluoro-4-aminobenzoic acid 
• 72-89-9 acetylcoenzyme A 
• 402-67-5 3-fluoro-1-nitrobenzene 
• 2369-20-2 N-(3-fluorophenyl)hydroxylamine 
• 399-96-2 4-amino-2-fluorophenol 
• 108-24-7 acetic anhydride 
• 123-54-6 acetylacetone 
• 403-19-0 2-fluoro-4-nitrophenol 
• 366-99-4 3-fluoro-4-methoxyaniline 
• 452-15-3 N-(3-fluoro-4-methoxyphenyl)acetamide 

Downstream Products

• 155020-43-2 3-<(diethylamino)methyl>-5-fluoro-4-hydroxyacetanilide 
• 868733-51-1 N-(4-(2-chloropyridin-4-yloxy)-3-fluorophenyl)acetamide 
• 1025986-25-7 4-Amino-2-diethylaminomethyl-6-fluoro-phenol 

Relevant articles and documents

De novo biosynthesis and whole-cell catalytic production of paracetamol on a gram scale in Escherichia coli

The synthetic drug paracetamol is one of the most commonly used analgesic, antipyretic agents around the world. Global massive demand promoted its synthesis in large quantities. Chemical synthesis is the main approach for paracetamol production. However, the reaction process contributes toward environmental pollution, and the reaction conditions are harsh. Herein, we reported the construction of the paracetamol de novo biosynthetic pathway in Escherichia coli. Five enzymes from different microbial sources were heterologously expressed into E. coli to construct the APAP (1) producing strain PA1. Through protein engineering of ABH (4-aminobenzoate hydroxylase) and PANAT (arylamine N-acetyltransferase), enhancement of the host cell resistance to the substrate or final product, and utilizing synthetic protein scaffolds to optimize the metabolic flux, the engineered strain could produce 942.5 mg L-1 (6.24 mM) paracetamol in a fed-batch 5 L fermenter directly from glucose or glycerol, which circumvents the fossil fuel resource use. Moreover, we established a whole-cell cascade biocatalytic synthesis way to paracetamol and analogues. Using p-aminobenzoate as the substrate, 4.2 g L-1 (27.7 mM) paracetamol can be formed after 9 h (95% conversion rate). After metabolic engineering, enzyme molecular modification, and other optimizations, we created the biotransformation strategy to manufacture paracetamol on a gram scale. This study provides a promising green and efficient alternative to the traditional chemical manufacturing method.

Substituted pyridazinone compound and application thereof

The invention provides a substituted pyridazinone compound and application thereof. The substituted pyridazinone compound is a compound shown in a general formula I, or a pharmaceutically acceptable salt, a prodrug, a hydrate or a solvent compound, a poly

H2O2-mediated oxidative formation of amides from aromatic amines and 1,3-diketones as acylation agents via C-C bond cleavage at room temperature in water under metal-free conditions

1,3-Diketones, as novel acylation agents, reacted with aromatic amines promoted by commercially available H2O2 (30% aq.) as the sole oxidant at room temperature under metal-free conditions in water, leading to a novel and rapid amide bond formation strategy. The reported method is high-yielding, simple and mild, and is the first example of the use of 1,3-diketones as acylation agents via C-C bond cleavage.