2050-85-3

Basic information

• Product Name: N1-[2-(ACETYLAMINO)PHENYL]ACETAMIDE
• Synonyms: N1-[2-(ACETYLAMINO)PHENYL]ACETAMIDE;1,2-diacetamidobenzene;N,N'-(o-phenylene)di(acetamide);N,N''-2-PHENYLENEBISACETAMIDE;1,2-Bis(acetylamino)benzene;N,N'-(2,1-Phenylene)bisacetamide;N,N'-Diacetylbenzene-1,2-diamine;N-[2-(Acetylamino)phenyl]acetamide
• CAS NO: 2050-85-3
• Molecular Formula: C₁₀H₁₂N₂O₂
• Molecular Weight: 192.21
• EINECS: 218-106-2
• Mol File: 2050-85-3.mol
• Article Data: 26

Chemical Properties

• Melting Point: 183 °C
• Boiling Point: 464.4 °C at 760 mmHg
• Flash Point: 210 °C
• Appearance: /
• Density: 1.235 g/cm³
• Storage Temp.: Sealed in dry,Room Temperature
• CAS DataBase Reference: N1-[2-(ACETYLAMINO)PHENYL]ACETAMIDE(CAS DataBase Reference)
• NIST Chemistry Reference: N1-[2-(ACETYLAMINO)PHENYL]ACETAMIDE(2050-85-3)
• EPA Substance Registry System: N1-[2-(ACETYLAMINO)PHENYL]ACETAMIDE(2050-85-3)

Safety Data

• Hazardous Substances Data: 2050-85-3(Hazardous Substances Data)

Usage

General Description

N1-[2-(acetylamino)phenyl]acetamide is a chemical compound with the molecular formula C10H11NO2. It is classified as an acetanilide, a derivative of acetamide that is used in the production of various pharmaceutical drugs and as an intermediate in organic synthesis. The compound is a white to off-white crystalline solid that is sparingly soluble in water. N1-[2-(acetylamino)phenyl]acetamide has been studied for its potential analgesic and anti-inflammatory properties, and it is also used as a precursor in the synthesis of other organic compounds. It is important to handle and use this chemical with caution, as it may have potential health hazards if not handled properly.

Upstream product

• 51-17-2 benzoimidazole 
• 127-09-3 sodium acetate 
• 108-24-7 acetic anhydride 
• 34801-09-7 N-(2-aminophenyl)acetamide 
• 60-29-7 diethyl ether 
• 95-54-5 1,2-diamino-benzene 
• 88-74-4 2-nitro-aniline 
• 75-36-5 acetyl chloride 
• 546-67-8 lead(IV) tetraacetate 
• 65182-17-4 5,12-dihydro-5,12-diacetylquinoxalino<2,3-b>quinoxaline 
• 507-09-5 thioacetic acid 
• 7732-18-5 water 
• 552-32-9 o-nitroacetanilide 
• 64-19-7 acetic acid 

Downstream Products

• 615-15-6 2-Methyl-1H-benzimidazole 
• 34801-09-7 N-(2-aminophenyl)acetamide 
• 23562-52-9 N,N'-(4,5-dichloro-o-phenylene)-bis-acetamide 
• 3213-79-4 N,N'-dimethyl-1,2-phenylenediamine 
• 221293-84-1 N-ferrocenyl-N,N'-diacetyl-o-phenylenediamine 
• 5805-76-5 1-ethyl-2-methyl-1H-benzo[d]imidazole 
• 1422740-72-4 N-{2-[acetyl(allyl)amino]phenyl}-N-allylacetamide 
• 928171-64-6 (2-bp)Au(N(COMe)C₆H₄NH(COMe))Cl 
• 928171-51-1 (2-bp)Au(N(COMe)C₆H₄N(COMe)) 
• 56842-62-7 5-acetamido-2-methylbenzimidazole 
• 22177-15-7 1,2,4-triaminobenzene N¹,N²-diacetate 
• 30120-73-1 1,2,4-triaminobenzene N¹,N²,N⁴-triacetate 
• 1792-40-1 2-methyl-5-nitrobenzimidazole 
• 28394-83-4 N,N'-diphenyl-o-phenylenediamine 

Relevant articles and documents

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The immobilized copper species on nickel ferrite (NiFe2O4@Cu): a magnetically reusable nanocatalyst for one-pot and quick reductive acetylation of nitroarenes to N-arylacetamides

In this study, a green protocol for synthesis of N-arylacetamides was introduced. Magnetically, nanoparticles of the immobilized copper species on nickel ferrite, NiFe2O4@Cu, were synthesized and then characterized using SEM, EDX, XRD, VSM, ICP-OES, BET and XPS analyses. The XPS analysis approved that the immobilized copper species on NiFe2O4 only contain Cu(0) and its oxide form as CuO. The prepared nanocomposite system represented a perfect catalytic activity toward one-pot and quick reductive acetylation of various nitroarenes to the corresponding N-arylacetamides. All reactions were carried out in a mixture of H2O–EtOH (1.5–0.5) within 2–10?min using the combination system of NaBH4 and Ac2O in a one-pot approach and via a two-step procedure. The utilized Cu nanocomposite was magnetically separated from the reaction mixture and reused for 5 consecutive cycles without the significant loss of its catalytic activity.

Synthesis of diverse libraries of carboxamides via chemoselective N-acylation of amines by carboxylic acids employing Br?nsted acidic IL [BMIM(SO3H)][OTf]

Chemoselective N-acylation of amines with carboxylic acids as acyl electrophiles and Br?nsted acidic IL [BMIM(SO3H)][OTf] as promoter is reported under both thermal and microwave irradiation to produce libraries of carboxamides in good to excellent yields after a simple workup. The protocol is compatible with structurally diverse 1° and 2° amines and works in the presence of sensitive functional groups such as thiols and phenols. The potential for recycling and reuse of the IL is also demonstrated.