2052-92-8

Basic information

• Product Name: 3-METHYL-4-PHENYLPYRIDINE
• Synonyms: 3-METHYL-4-PHENYLPYRIDINE
• CAS NO: 2052-92-8
• Molecular Formula: C₁₂H₁₁N
• Molecular Weight: 169.22
• Mol File: 2052-92-8.mol
• Article Data: 19

Chemical Properties

• Boiling Point: 267.6 °C at 760 mmHg
• Flash Point: 109 °C
• Appearance: /
• Density: 1.03 g/cm³
• Vapor Pressure: 0.0133mmHg at 25°C
• Refractive Index: 1.568
• CAS DataBase Reference: 3-METHYL-4-PHENYLPYRIDINE(CAS DataBase Reference)
• NIST Chemistry Reference: 3-METHYL-4-PHENYLPYRIDINE(2052-92-8)
• EPA Substance Registry System: 3-METHYL-4-PHENYLPYRIDINE(2052-92-8)

Safety Data

• Hazardous Substances Data: 2052-92-8(Hazardous Substances Data)

Usage

Synthesis Reference(s)

Journal of Heterocyclic Chemistry, 12, p. 709, 1975 DOI: 10.1002/jhet.5570120419

InChI:InChI=1/C12H11N/c1-10-9-13-8-7-12(10)11-5-3-2-4-6-11/h2-9H,1H3

Upstream product

• 13515-63-4 1,3-dimethyl-4-phenyl-1,2,5,6-tetrahydropyridine 
• 14371-10-9 (E)-3-phenylpropenal 
• 2450-71-7 Propargylamine 
• 15430-52-1 prop-2-yn-1-amine hydrochloride 
• 108-99-6 3-Methylpyridine 
• 71-43-2 benzene 
• 104-55-2 3-phenyl-propenal 
• 591-50-4 iodobenzene 
• 4733-71-5 1,3-dimethyl-4-phenyl-piperidin-4-ol 
• 132368-30-0 N-ethoxycarbonyl-3-methylpyridinium chloride 
• 106-51-4 p-benzoquinone 
• 114655-48-0 (E)-2-methyl-N-((E)-3-phenylallylidene)propan-2-amine 
• 123-38-6 propionaldehyde 
• 83476-28-2 3-Methyl-4-phenyl-pyridine-2,6-dicarboxylic acid 

Downstream Products

• 95969-41-8 1,5-dimethyl-4-phenyl-1,2,3,6-tetrahydropyridine N-oxide 
• 13515-63-4 1,3-dimethyl-4-phenyl-1,2,5,6-tetrahydropyridine 
• 95968-88-0 1,3-dimethyl-4-phenylpyridinium iodide 
• 113120-10-8 3-methyl-4-(4-nitrophenyl)pyridine 

Relevant articles and documents

NOVEL METHODS FOR PREPARATION OF SUBSTITUTED PYRIDINES AND RELATED NOVEL COMPOUNDS

The present invention relates to novel methods of preparation of substituted pyridines and the compounds produced therefrom. In particular, the present invention provides efficient methods for the construction of diversely substituted pyridines, with varying substitution patterns under simple and metal-free conditions with high atom- and pot-economy and excellent functional group tolerance, and which are useful for the synthesis of natural products.

Facile Synthesis of Pyridines from Propargyl Amines: Concise Total Synthesis of Suaveoline Alkaloids

A general and efficient protocol was developed for the synthesis of polysubstituted pyridines from propargyl amines and unsaturated carbonyl compounds through a tandem condensation/alkyne isomerization/6π 3-azatriene electrocyclization sequence. This process was found to be applicable to a wide range of readily available substrates (30 examples, up to 95 % yield) and could be readily performed on a preparative (20 g) scale. By taking advantage of this method for late-stage pyridine incorporation, we successfully completed the collective total synthesis of suveoline, norsuveoline, and macrophylline.