205510-53-8

Basic information

• Product Name: (E)-1-(2-CHLORO-5-THIAZOLYLMETHYL)-3-METHYL-2-NITROGUANIDINE
• Synonyms: 1-(2-Chloro-5-thiazolylmethyl)-3-methyl-2-nitroguanidine;Clothianidin;Guanidine, N-(2-chloro-5-thiazolyl)methyl-N'-methyl-N''-nitro-, (E)-
• CAS NO: 205510-53-8
• Molecular Formula: C6H8ClN5O2S
• Molecular Weight: 249.681
• Mol File: 205510-53-8.mol
• Article Data: 20

Chemical Properties

• Melting Point: 178.8℃
• Boiling Point: 435.2 °C at 760 mmHg
• Flash Point: 217 °C
• Appearance: /
• Density: 1.68 g/cm³
• Vapor Pressure: 8.93E-08mmHg at 25°C
• Refractive Index: 1.709
• Water Solubility: 327 mg/L at 20℃
• CAS DataBase Reference: (E)-1-(2-CHLORO-5-THIAZOLYLMETHYL)-3-METHYL-2-NITROGUANIDINE(CAS DataBase Reference)
• NIST Chemistry Reference: (E)-1-(2-CHLORO-5-THIAZOLYLMETHYL)-3-METHYL-2-NITROGUANIDINE(205510-53-8)
• EPA Substance Registry System: (E)-1-(2-CHLORO-5-THIAZOLYLMETHYL)-3-METHYL-2-NITROGUANIDINE(205510-53-8)

Safety Data

• Hazardous Substances Data: 205510-53-8(Hazardous Substances Data)

Usage

General Description

The chemical compound (E)-1-(2-chloro-5-thiazolylmethyl)-3-methyl-2-nitroguanidine is an organic compound with the molecular formula C6H7ClN5O2S. It is a nitroguanidine derivative with a thiazole ring and a chlorine atom attached to the thiazole ring. (E)-1-(2-CHLORO-5-THIAZOLYLMETHYL)-3-METHYL-2-NITROGUANIDINE has potential applications in the pharmaceutical industry as an intermediate for the synthesis of other organic compounds. It may also have uses in agricultural products, as it has properties that could make it suitable for use as a pesticide or herbicide. Additionally, its structure and chemical properties make it of interest for further research in the field of organic chemistry and chemical synthesis.

InChI:InChI=1/C6H8ClN5O2S/c1-8-6(11-12(13)14)10-3-4-2-9-5(7)15-4/h2H,3H2,1H3,(H2,8,10,11)

Upstream product

• 187149-02-6 O-methyl-N-(2-chloro-5-thiazolylmethyl)-N'-nitroisourea 
• 187149-02-6 O-methyl-(2-chloro-5-thiazolylmethyl)-N'-nitroisourea 
• 74-89-5 methylamine 
• 136516-19-3 1-[(2-chloro-5-thiazolyl)methyl]tetrahydro-3,5-dimethyl-N-nitro-1,3,5-triazin-2(1H)-imine 
• 120740-08-1 [(2-chloro-5-thiazolyl)methyl]amine 
• 57538-27-9 2-methyl-1-nitroisourea 
• 305838-80-6 C₁₀H₁₅ClN₆O₂S 

Relevant articles and documents

A novel method for the preparation of N,N'-disubstituted-N'-nitroguanidines, including a practical synthesis of the neonicotinoid insecticide clothianidin

A novel method is described for the synthesis of N,N'-disubstituted-N'-nitroguanidines 3 via 2-nitroimino-hexahydro-1,3,5-triazine intermediates 12, allowing the introduction of the heteroarylmethyl group either from a heteroarylmethyl amine 9 or a heteroarylmethyl chloride 14, respectively. This method enables an efficient synthesis of the neonicotinoid insecticide clothianidin (3b) in four steps from S-methyl-N-nitro-isothiourea (10). (C) 2000 Elsevier Science Ltd.

Production of compounds

Provided is a method for producing a compound represented by formula (2), or a salt thereof, by reacting ammonia with formaldehyde so as to obtain a mixture that contains a compound represented by formula (8), and then mixing the obtained mixture that contains the compound represented by formula (8) with a compound represented by formula (1), or a salt thereof, in the presence of a base.

NOXIOUS ARTHROPOD CONTROL AGENT CONTAINING AMIDE COMPOUND

An object of the present invention is to provide a compound having the controlling activity on a noxious arthropod, and a noxious arthropod controlling agent containing an amide compound of formula (I): wherein X represents a nitrogen atom or a CH group, p represents 0 or 1, A represents a tetrahydrofuranyl group or the like, R1, R2, R3, R4, R5, R6 and R7 represent a hydrogen atom or the like, n represents 1 or 2, Y represents an oxygen atom or the like, m represents any integer of 0 to 7, and Q represents a C1-8 chain hydrocarbon group optionally having a phenyl group or the like, has the excellent noxious arthropod controlling effect.