20577-27-9 Usage
Description
2-Hydroxy-3-cyanopyridine, with the CAS number 20577-27-9, is a chemical compound characterized by its dark yellow solid appearance. It is primarily utilized in the field of organic synthesis, playing a crucial role in the creation of various organic molecules.
Uses
Used in Organic Synthesis:
2-Hydroxy-3-cyanopyridine is used as a synthetic building block for the development of complex organic molecules. Its unique structure, which includes a hydroxyl and a cyano group attached to a pyridine ring, allows it to participate in a wide range of chemical reactions, making it a valuable component in the synthesis of pharmaceuticals, agrochemicals, and other specialty chemicals.
Used in Pharmaceutical Industry:
In the pharmaceutical industry, 2-Hydroxy-3-cyanopyridine is used as a key intermediate in the synthesis of various drug candidates. Its presence in the molecular structure can contribute to the desired biological activity, such as enhancing the drug's potency, selectivity, or stability.
Used in Agrochemical Industry:
2-Hydroxy-3-cyanopyridine also finds application in the agrochemical industry, where it is employed as a starting material for the synthesis of novel pesticides, herbicides, and other crop protection agents. Its incorporation into these molecules can lead to improved efficacy and selectivity, ultimately benefiting agricultural productivity and sustainability.
Used in Dye and Pigment Industry:
In the dye and pigment industry, 2-Hydroxy-3-cyanopyridine is used as a precursor for the synthesis of various dyes and pigments. Its dark yellow solid form can be further modified to produce a range of colors, which can be utilized in the textile, plastics, and printing industries.
Used in Research and Development:
2-Hydroxy-3-cyanopyridine is also used in research and development settings, where it serves as a valuable tool for understanding the fundamental chemical properties and reactivity patterns of similar compounds. Its study can lead to the discovery of new synthetic routes, applications, and insights into the broader field of organic chemistry.
Check Digit Verification of cas no
The CAS Registry Mumber 20577-27-9 includes 8 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 5 digits, 2,0,5,7 and 7 respectively; the second part has 2 digits, 2 and 7 respectively.
Calculate Digit Verification of CAS Registry Number 20577-27:
(7*2)+(6*0)+(5*5)+(4*7)+(3*7)+(2*2)+(1*7)=99
99 % 10 = 9
So 20577-27-9 is a valid CAS Registry Number.
InChI:InChI=1/C6H4N2O/c7-4-5-2-1-3-8-6(5)9/h1-3H,(H,8,9)
20577-27-9Relevant articles and documents
Pyrazolopyridine hydroxamic acid compound as well as preparation method and application thereof
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Paragraph 0030; 0034-0036, (2021/09/01)
The invention relates to the technical field of chemical synthesis, in particular to a pyrazolopyridine hydroxamic acid compound as well as a preparation method and application thereof. The pyrazolopyridine hydroxamic acid compound comprises a compound as shown in a formula (1), an isomer thereof, and a hydrate thereof or a pharmaceutically acceptable salt thereof, wherein n is an integer, and R is any one of a substituted or unsubstituted aromatic ring group and a substituted alkyl group. The compound can well inhibit cancer cell proliferation, and then has an excellent treatment effect on tumors.
Pyrazolopyridine or indazole derivatives as protein kinase inhibitors
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Paragraph 0173-0180, (2019/03/01)
The present invention relates to novel pyrazolopyridine or indazole derivatives having inhibitory activity against protein kinases or pharmaceutically acceptable salts thereof. Since compounds of the present invention have excellent inhibitory activity against to protein kinases, for example, ABL, ACK1, ALK, Aurora A, Aurora B, Aurora C, BLK, BMX/ETK, BRSK1, BTK, c-Src, CAMKK, CDK1, CDK2, CDK5, CLK, DDR, DYRK1B, EPHA, EPHB, FAK/PTK2, FER, FES/FPS, FGFR, FGR, FLT3, FLT4/VEGFR3, FMS, FRK/PTK5, FYN, GSK3b, HCK, IGF1R, IR, IRAK1, IRR/INSRR, ITK, JAK2, KHS/MAP4K5, LCK, LYN, PHKg, PLK4/SAK, PYK2, RET, ROS/ROS1, TIE2/TEK, TRK, TXK, TYK, YES/YES1, and the like, the compounds are useful for treatment and prevention of various kinds of cancer diseases.
Design and synthesis of novel substituted naphthyridines as potential c-Met kinase inhibitors based on MK-2461
Wu, Jing-Fang,Liu, Ming-Ming,Huang, Shao-Xu,Wang, Yang
supporting information, p. 3251 - 3255 (2015/07/08)
Abstract Two series of novel 1,5-naphthyridine and 1,6-naphthyridine derivatives were designed and synthesized based on the c-Met kinase inhibitor MK-2461 under the guidance of scaffold hopping strategy. All were tested on c-Met kinase and in vitro anti-tumor activities against Hela and A549 cell lines. The results indicated that 1,6-naphthyridine was a more promising c-Met inhibitory structure core compared with 1,5-naphthyridine. Among them, 26b and 26c showed the best enzymic and cytotoxic activities. The western blot experiments implied that the cytotoxic activity of 26c might be partially through suppressing the phosphorylation of c-Met kinase.
