205827-96-9

Basic information

• Product Name: GW9662
• Synonyms: GW9662;2-CHLORO-5-NITROBENZANILIDE;2-CHLORO-5-NITRO-N-PHENYLBENZAMIDE;TIMTEC-BB SBB006523
• CAS NO: 205827-96-9
• Molecular Formula: C₁₃H₉ClN₂O₃
• Molecular Weight: 276.68
• Product Categories: Aromatic Carboxylic Acids, Amides, Anilides, Anhydrides & Salts
• Mol File: 205827-96-9.mol
• Article Data: 5

Chemical Properties

• Melting Point: 171-175 °C(lit.)
• Boiling Point: 330.4±32.0 °C(Predicted)
• Appearance: white/solid
• Density: 1.440±0.06 g/cm3(Predicted)
• Storage Temp.: 2-8°C
• Solubility: DMSO: 26 mg/mL, soluble
• PKA: 11.66±0.70(Predicted)
• CAS DataBase Reference: GW9662(CAS DataBase Reference)
• NIST Chemistry Reference: GW9662(205827-96-9)
• EPA Substance Registry System: GW9662(205827-96-9)

Safety Data

• Hazard Codes: Xi
• Statements: 36-43
• Safety Statements: 26-36/37
• WGK Germany: 3
• Hazardous Substances Data: 205827-96-9(Hazardous Substances Data)

Usage

General Description

GW9662 is a selective antagonist of peroxisome proliferator-activated receptor gamma (PPARγ) and is commonly used in research as a tool to investigate the role of PPARγ in various physiological processes. It has been shown to inhibit the activation of PPARγ and thereby block the downstream effects of PPARγ activation. This chemical has been used to study the involvement of PPARγ in a variety of biological processes, including adipocyte differentiation, insulin sensitivity, inflammation, and cancer. GW9662 is considered an important tool in understanding the role of PPARγ in health and disease, and its use in research has contributed to the development of potential therapeutic targets for various conditions.

Upstream product

• 611-73-4 Benzoylformic acid 
• 97-00-7 1-chloro-2,4-dinitro-benzene 
• 6283-25-6 H₂NC₆H₃(Cl)NO₂ 
• 98-88-4 benzoyl chloride 

Downstream Products

• 43087-91-8 2-phenyl-1,3-benzothiazol-5-amine 
• 1609355-65-8 N-(3-benzamido-4-chlorophenyl)-2-chloro-4-(3,3-dioxido-1,3,4-oxathiazinan-4-yl)benzamide 
• 1609355-55-6 N-(3-benzamido-4-chlorophenyl)-4-(3,3-dioxido-1,3,4-oxathiazinan-4-yl)-2-fluorobenzamide 
• 1609355-53-4 N-(3-benzamido-4-chlorophenyl)-2-chloro-4-(3,3-dioxido-1,3,4-oxathiazinan-4-yl)benzamide 
• 1609355-49-8 C₂₃H₁₉ClFN₃O₄S 
• 64448-50-6 5-nitro-2-phenyl-benzothiazole 
• 1372687-96-1 1-[N-(2-chloro-5-nitro-phenyl)-benzimidoyl]3-(4-methoxy phenyl) thiourea 
• 1372687-94-9 1-[N-(2-chloro-5-nitro-phenyl)-benzimidoyl] 3-(4-methyl phenyl) thiourea 
• 1372687-92-7 1-[N-(2-chloro-5-nitro-phenyl)-benzimidoyl]-3-phenyl thiourea 
• 1372687-87-0 N-(2-chloro-5-nitro-phenyl)-N'-cyclohexyl-benzamidine 
• 1372688-08-8 3-cyclohexyl 1-[N-(2-chloro-5-nitro-phenyl)-benzimidoyl]thiourea 

Relevant articles and documents

Decarboxylative/Oxidative Amidation of Aryl α-Ketocarboxylic Acids with Nitroarenes and Nitroso Compounds in Aqueous Medium

The decarboxylative/oxidative amidation of aryl α-ketocarboxylic acids with 5-aryl-3-nitroisoxazole-4-carboxylates and substituted dinitrobenzenes under oxidative aqueous conditions to afford N-aryl amides is described. The reaction is suggested to proceed via a radical pathway in which a benzoyl nitroxyl radical, the key intermediate formed from reaction between nitroarene and benzoyl radical from glyoxalic acid, couples with hydroxyl radical from water to produce amide. Mechanistic insight allowed the scope of the strategy to be expanded to the synthesis of amides via reaction between aryl α-ketocarboxylic acids and nitroso compounds.

COMPOUNDS FOR TREATMENT OF TRYPANOSOMES AND NEUROLOGICAL PATHOGENS AND USES THEREOF

The present invention relates to novel compounds that cross the blood-brain barrier and are effective inhibitors of neurological pathogens such as trypanosomes. The invention further relates to the use of these compounds for treating disorders related to trypanosomes and neurological pathogens.

BISAMIDE INHIBITORS OF HEDGEHOG SIGNALING

The invention provides inhibitors of hedgehog signaling that are useful as a therapeutic agents for treating malignancies where the compounds have the general formula (I), wherein ring A, ring B, R1, R2, R3, R4,