205873-58-1

Basic information

• Product Name: Indole-7-carboxylic acid ethyl ester
• Synonyms: 1H-Indole-7-carboxylicacid,ethylester(9CI);1H-Indole-7-carboxylic acid ethyl ester;Indole-7-carboxylic acid ethyl ester;Ethyl 1H-indole-7-carboxylate
• CAS NO: 205873-58-1
• Molecular Formula: C11H11NO2
• Molecular Weight: 189.21
• Product Categories: CARBOXYLICESTER
• Mol File: 205873-58-1.mol
• Article Data: 5

Chemical Properties

• Boiling Point: 342.357 °C at 760 mmHg
• Flash Point: 160.852 °C
• Appearance: /
• Density: 1.211 g/cm³
• Vapor Pressure: 0mmHg at 25°C
• Refractive Index: 1.621
• Storage Temp.: Sealed in dry,Room Temperature
• PKA: 15.42±0.30(Predicted)
• CAS DataBase Reference: Indole-7-carboxylic acid ethyl ester(CAS DataBase Reference)
• NIST Chemistry Reference: Indole-7-carboxylic acid ethyl ester(205873-58-1)
• EPA Substance Registry System: Indole-7-carboxylic acid ethyl ester(205873-58-1)

Safety Data

• Hazardous Substances Data: 205873-58-1(Hazardous Substances Data)

Usage

General Description

Indole-7-carboxylic acid ethyl ester is a chemical compound that belongs to the indole class of organic compounds. It is commonly used in the synthesis of pharmaceuticals and agrochemicals, as well as in the production of perfumes and fragrances. Indole-7-carboxylic acid ethyl ester is known for its distinct odor and is often used as a flavoring agent in the food industry. Additionally, it has been studied for its potential biological activities, including anti-inflammatory and anticancer effects. Overall, indole-7-carboxylic acid ethyl ester is a versatile chemical with various industrial and medicinal applications.

InChI:InChI=1/C11H11NO2/c1-2-14-11(13)9-5-3-4-8-6-7-12-10(8)9/h3-7,12H,2H2,1H3

Upstream product

• 109-97-7 pyrrole 
• 1630933-14-0 (E)-ethyl 2-diazo-5-oxopent-3-enoate 
• 1670-83-3 1H-Indole-7-carboxylic acid 
• 64-17-5 ethanol 

Downstream Products

• 167479-16-5 1-methylindolyl-7-carboxylic acid 

Relevant articles and documents

RhCl3·3H2O-Catalyzed C7-Selective C-H Carbonylation of Indolines with CO and Alcohols

An attractive method for the synthesis of indoline-7-carboxylates through RhCl3-catalyzed C-H carbonylation of indolines with CO and alcohols was developed. The copper-based oxidant and removable pyrimidyl directing group played important roles in achieving high-level yields of the title products. Based on control experiments, a possible catalytic cycle was proposed.

Noncovalent Interactions in Ir-Catalyzed C-H Activation: L-Shaped Ligand for Para-Selective Borylation of Aromatic Esters

An efficient strategy for the para-selective borylation of aromatic esters is described. For achieving high para-selectivity, a new catalytic system has been developed modifying the core structure of the bipyridine. It has been proposed that the L-shaped ligand is essential to recognize the functionality of the oxygen atom of the ester carbonyl group via noncovalent interaction, which provides an unprecedented controlling factor for para-selective C-H activation/borylation.

A new one-pot synthesis of polysubstituted indoles from pyrroles and β-nitroacrylates

The reaction of β-nitroacrylates with pyrroles, under solvent- and catalyst-free conditions, allows the formation of Friedel-Crafts adducts which, after in situ treatment with Amberlyst 15 in isopropyl alcohol under reflux, provide polysubstituted indoles, via a benzannulation reaction, in a one-pot process. Copyright