206055-86-9

Basic information

• Product Name: [3-(4-METHOXY-PHENYL)-ISOXAZOL-5-YL]-METHANOL
• Synonyms: 5-(Hydroxymethyl)-3-(4-methoxyphenyl)isoxazole;5-(Hydroxymethyl)-3-(4-methoxyphenyl)isoxazole, 4-[5-(Hydroxymethyl)isoxazol-3-yl]anisole;[3-(4-METHOXYPHENYL)-5-ISOXAZOLYL]METHANOL;[3-(4-METHOXY-PHENYL)-ISOXAZOL-5-YL]-METHANOL;(3-(4-methoxyphenyl)isoxazol-5;Methoxyphenylisoxazolylmethanol;[3-(4-methoxyphenyl)-1,2-oxazol-5-yl]methanol
• CAS NO: 206055-86-9
• Molecular Formula: C₁₁H₁₁NO₃
• Molecular Weight: 205.21
• EINECS: 604-604-1
• Product Categories: API intermediates;pharmacetical
• Mol File: 206055-86-9.mol
• Article Data: 22

Chemical Properties

• Melting Point: 97-98°C
• Boiling Point: 396.1±37.0 °C(Predicted)
• Appearance: /
• Density: 1.217±0.06 g/cm3(Predicted)
• PKA: 13.32±0.10(Predicted)
• CAS DataBase Reference: [3-(4-METHOXY-PHENYL)-ISOXAZOL-5-YL]-METHANOL(CAS DataBase Reference)
• NIST Chemistry Reference: [3-(4-METHOXY-PHENYL)-ISOXAZOL-5-YL]-METHANOL(206055-86-9)
• EPA Substance Registry System: [3-(4-METHOXY-PHENYL)-ISOXAZOL-5-YL]-METHANOL(206055-86-9)

Safety Data

• Hazard Codes: Xi,Xn
• Statements: 22
• HazardClass: IRRITANT
• Hazardous Substances Data: 206055-86-9(Hazardous Substances Data)

Usage

General Description

[3-(4-Methoxy-phenyl)-isoxazol-5-yl]-methanol is a chemical compound that belongs to the class of isoxazole derivatives. It is composed of a methanol group attached to an isoxazole ring, which in turn is substituted with a 4-methoxyphenyl group. [3-(4-METHOXY-PHENYL)-ISOXAZOL-5-YL]-METHANOL may have potential applications in pharmaceutical research and drug development due to its structural properties and potential biological activities. As a result, it could be used as a building block in the synthesis of various biologically active compounds or as a reference standard in analytical chemistry. Further research and testing are necessary to fully understand the properties and potential uses of this chemical.

Upstream product

• 3717-21-3 p-methoxyl benzaldoxime 
• 6175-54-8 hydroxy-1-propyne 
• 35322-20-4 ethyl 3-(4-methoxybenzoyl)pyruvate 
• 100-06-1 1-(4-methoxyphenyl)ethanone 
• 123-11-5 4-methoxy-benzaldehyde 
• 107-19-7 propargyl alcohol 
• 3717-21-3 (E)-4-methoxybenzaldoxime 
• 15500-73-9 4-methoxybenzonitrile oxide 
• 38435-51-7 N-hydroxy-4-methoxy-benzenecarboximidoyl chloride 

Downstream Products

• 1308264-80-3 (3-(4-methoxyphenyl)isoxazol-5-yl)methyl 4-methylbenzenesulfonate 
• 61428-21-5 3-(4-methoxy-phenyl)-5-methylisoxazole 
• 1262439-62-2 tert-butyl (S)-1-((3-(4-methoxyphenyl)isoxazol-5-yl)methylcarbamoyl)-2-phenylethylcarbamate 
• 1262439-63-3 (S)-2-amino-N-((3-(4-methoxyphenyl)isoxazol-5-yl)methyl)-3-phenylpropaneamide 
• 1262439-64-4 benzyl (S)-1-((3-(4-methoxyphenyl)isoxazol-5-yl)methylcarbamoyl)-2-methylpropyl carbamate 
• 1262439-67-7 benzyl 2-((3-(4-methoxyphenyl)isoxazol-5-yl)methylamino)-2-oxoethylcarbamate 
• 1262439-68-8 tert-butyl (S)-1-((3-(4-methoxyphenyl)isoxazol-5-yl)methylcarbamoyl)-2-((benzyloxy)carbonyl)ethylcarbamate 
• 1262439-70-2 isobutyl ((3-(4-methoxyphenyl)isoxazol-5-yl)methyl)carbamate 
• 1262439-71-3 2-bromo-N-((3-(4-methoxyphenyl)isoxazol-5-yl)methyl)ethaneamide 
• 1262439-59-7 5-(azidomethyl)-3-(4-methoxyphenyl)isoxazole 
• 338982-43-7 1-(3-(4-methoxyphenyl)isoxazol-5-yl)methaneamine 
• 1204422-46-7 4-{3-[3-(4-hydroxyphenyl)-4-ethylisoxazol-5-yl]propanoyl}amino-1-ethylpyrrole-3-carboxylic acid 
• 1204422-43-4 4-{3-[3-(4-Hydroxyphenyl)-4-ethylisoxazol-5-yl]-2-fluoropropanoyl}amino-1-ethylpyrrole-3-carboxylic acid 
• 196877-76-6 5-(bromomethyl)-3-(4-methoxyphenyl)isoxazole 

Relevant articles and documents

Solvatochromic and solid-state emissive azlactone-based AIEE-active organic dye: Synthesis, photophysical properties and color-conversion LED application

Here, we report one-pot synthesis of a new azlactone-based dye bearing isoxazole moiety as a donor group (i.e., Dye-Iso), which displays fluorescence emission both in solution and solid-state, and a systematic study of its photophysical properties. The an

Synthesis, cytotoxic activity and binding model analysis of novel isoxazole-docetaxel analogues with C3′-N modification

Structure–activity relationship (SAR) studies confirm that modifications at C-3′ position can lead to the development of highly potent novel taxoids. We designed and synthesized a series of novel isoxazole-docetaxel analogues A1–A5 by introducing isoxazol

Synthesis of new arylisoxazole–oxindole conjugates as potent antiproliferative agents

A new series of arylisoxazole–oxindole derivatives (6a–r) were synthesized and evaluated for their antiproliferative activity against human cancer cell lines including non-small cell lung (A549), cervical (HeLa), breast (MCF-7), and prostate (DU-145) cancer cell lines. The synthesized compounds (6a–r) demonstrated excellent to moderate cytotoxicity with IC50 values ranging from 0.82 to 3.69?μm. Some new compounds (6m–r) exhibited profound cytotoxicity better or similar to positive control. More particularly, the compound 6q possesses donating substituent like methoxy group presented at 5-position on D ring exhibited remarkable antiproliferative activity against A-549 (lung cancer) with an IC50 value 0.82?μm. Further studies to determine the mechanistic aspects of these conjugates are under progress.