206184-49-8

Basic information

• Product Name: 9-[(R)-2-(Phosphonomethoxy)propyl]adenine monohydrate
• Synonyms: 9-[(R)-2-(Phosphonomethoxy)propyl]adenine monohydrate;(r)-[[2-(6-amino-9h-purin-9-yl)-1-methylethoxy]methyl]-phosphonic acid monohydrate;Unii-99yxe507il;Tenofovir Monohydrate;Tenofovir (15 mg);Tenofovir (hydrate);PMPA Monohydrate;(R)-(((1-(6-Amino-9H-purin-9-yl)propan-2-yl)oxy)methyl)phosphonic acid hydrate
• CAS NO: 206184-49-8
• Molecular Formula: C9H16N5O5P
• Molecular Weight: 305.23
• EINECS: 1312995-182-4
• Product Categories: ALIMTA
• Mol File: 206184-49-8.mol
• Article Data: 0

Chemical Properties

• Boiling Point: 616.1ºC at 760mmHg
• Flash Point: 326.4ºC
• Appearance: /
• Density: 1.79g/cm3
• Storage Temp.: 2-8°C
• Solubility: Aqueous Acid (Slightly), DMSO (Slightly)
• Stability: Hygroscopic
• CAS DataBase Reference: 9-[(R)-2-(Phosphonomethoxy)propyl]adenine monohydrate(CAS DataBase Reference)
• NIST Chemistry Reference: 9-[(R)-2-(Phosphonomethoxy)propyl]adenine monohydrate(206184-49-8)
• EPA Substance Registry System: 9-[(R)-2-(Phosphonomethoxy)propyl]adenine monohydrate(206184-49-8)

Safety Data

• Hazardous Substances Data: 206184-49-8(Hazardous Substances Data)

Usage

Chemical Properties

WHITE POWDER SOLID

Uses

Different sources of media describe the Uses of 206184-49-8 differently. You can refer to the following data:
1. Tenofovir Monohydrate is an HIV-1 RT inhibitor and antiretroviral drug.
2. antineoplastic, thymidylate synthase inhibitor

Definition

ChEBI: A hydrate that is the monohydrate form of anhydrous tenovir.

General Description

Pharmaceutical secondary standards for application in quality control, provide pharma laboratories and manufacturers with a convenient and cost-effective alternative to the preparation of in-house working standards. Tenofovir is a nucleotide analog reverse transcriptase inhibitor, and is widely used as an antiretroviral agent, for the treatment of HIV infection.

Biological Activity

tenofovir hydrate is an inhibitor of reverse transcriptase used for the treatment of the human immunodeficiency virus 1(hiv-1) and hepatitis b [1].tenofovir hydrate is an antiviral pro-drug and the class of nucleoside reverse transcriptase inhibitor. in addition, tenofovir hydrate has been reported to have a dependent relation between intracellular the drug concentrations and prevent function of hiv-1infection with ec50 values of 29 fmol/106, 40 fmol/106 , 77 fmol/106 and 411 fmol/106 cells for inoculum size 1, 5, 20 and 100 respectively. and the ec90 values of tenofovir hydrate are 267 fmol/106, 348 fmol/106, 640 fmol/106 and 2866 fmol/106 cells for virus inoculums size 1, 5, 20 and 100, respectively [1].

InChI:InChI=1/C9H14N5O4P.H2O/c1-6(18-5-19(15,16)17)2-14-4-13-7-8(10)11-3-12-9(7)14;/h3-4,6H,2,5H2,1H3,(H2,10,11,12)(H2,15,16,17);1H2/t6-;/m1./s1