206646-04-0 Usage
Chemical Properties
White Solid
Uses
Different sources of media describe the Uses of 206646-04-0 differently. You can refer to the following data:
1. A metabolite of Tenofovir (T018500).This compound contains an undetermined amout of water and phosphoric acid.
2. A metabolite of Tenofovir.
This compound contains an undetermined amout of water and phosphoric acid
3. A metabolite of Tenofovir (T018500).
This compound contains an undetermined amout of water and phosphoric acid.
Check Digit Verification of cas no
The CAS Registry Mumber 206646-04-0 includes 9 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 6 digits, 2,0,6,6,4 and 6 respectively; the second part has 2 digits, 0 and 4 respectively.
Calculate Digit Verification of CAS Registry Number 206646-04:
(8*2)+(7*0)+(6*6)+(5*6)+(4*4)+(3*6)+(2*0)+(1*4)=120
120 % 10 = 0
So 206646-04-0 is a valid CAS Registry Number.
InChI:InChI=1/C9H15N5O7P2/c1-6(20-5-22(15,16)21-23(17,18)19)2-14-4-13-7-8(10)11-3-12-9(7)14/h3-4,6H,2,5H2,1H3,(H,15,16)(H2,10,11,12)(H2,17,18,19)/t6-/m1/s1
206646-04-0Relevant articles and documents
Acyclic phosphonate nucleotides and human adenylate kinases: Impact of a borano group on α-P position
Topalis,Alvarez,Barral,Munier-Lehmann,Schneider,Veron,Guerreiro,Mulard,El-Amri,Canard,Deville-Bonne
, p. 319 - 331 (2008)
Adenylate kinases are involved in the activation of antiviral drugs such as the acyclic phosphonates analogs PMEA and (R)PMPA. We examine the in vitro phosphorylation of PMEA and PMPA bearing a borano- or a H- group on the phosphorus atom. The α-borano or α-H on PMEA and PMPA were detrimental to the activity of recombinant human AMP kinases 1 and 2. Docking PMEA to the active site of AMP kinase 1 indicated that the borano group may prevent two conserved critical Arg interactions with the α-phosphate, resulting in substrate bad positioning. Copyright Taylor & Francis Group, LLC.