20668-35-3

Basic information

• Product Name: 7,8-DiMethylquinoline
• Synonyms: 7,8-DiMethylquinoline
• CAS NO: 20668-35-3
• Molecular Formula: C₁₁H₁₁N
• Molecular Weight: 157.21174
• Mol File: 20668-35-3.mol
• Article Data: 7

Chemical Properties

• Appearance: /
• CAS DataBase Reference: 7,8-DiMethylquinoline(CAS DataBase Reference)
• NIST Chemistry Reference: 7,8-DiMethylquinoline(20668-35-3)
• EPA Substance Registry System: 7,8-DiMethylquinoline(20668-35-3)

Safety Data

• Hazardous Substances Data: 20668-35-3(Hazardous Substances Data)

Usage

General Description

7,8-Dimethylquinoline, also known as 7,8-DMQ, is an organic compound with a chemical formula C11H11N. It is a member of the quinoline family, which are aromatic heterocyclic compounds containing a benzene ring fused to a pyridine ring. 7,8-Dimethylquinoline is a pale yellow liquid with a strong odor. It is primarily used as a flavoring agent and is found naturally in certain foods and beverages. In addition, it is a key intermediate in the production of pharmaceuticals, dyes, and other organic compounds. The compound is also used in the manufacturing of insecticides, fungicides, and specialty chemicals. 7,8-Dimethylquinoline is considered to have low toxicity and is not expected to pose significant health risks when handled and used properly.

Upstream product

• 156-87-6 propan-1-ol-3-amine 
• 87-59-2 2,3-Dimethylaniline 
• 56-81-5 glycerol 

Downstream Products

• 1609646-82-3 N-((7-methylquinolin-8-yl)methyl)-4-(trifluoromethyl)benzenesulfonamide 

Relevant articles and documents

Three-Component Couplings among Heteroarenes, Difluorocyclopropenes, and Water via C-H Activation

Three-component couplings have been realized for efficiently constructing various nitrogen-containing skeletons via C-H activation, where difluorocyclopropenes have been first identified as coupling partners. Many substrates including sp2 and sp3 C-H substrates were well tolerated, furnishing the corresponding products in good yields. Furthermore, a catalyst-dependent reaction was also developed, enabling divergent construction of two different frameworks. The application value of these reactions was demonstrated in gram-scale experiments with as little as 1 mol % catalyst.

Cobalt-catalyzed ring-opening addition of azabenzonorbornadienes: Via C(sp3)-H bond activation of 8-methylquinoline

The first ring-opening addition of a benzylic C(sp3)-H bond to azabenzonorbornadienes is demonstrated. The reaction proceeded under the catalytic system of [Cp?CoI2(CO)], AgSbF6 and Fe(OAc)2 in PhOMe. The methodology showed a good substrate scope with up to 96 yield. The relative configuration of the product was determined as cis-configuration by X-ray crystallography.

Rh-Catalyzed Direct Amination of Unactivated C(sp3)?H bond with Anthranils Under Mild Conditions

C?N Bond formation is of great significance due to the ubiquity of nitrogen-containing compounds. Here, a mild and efficient RhIII-catalyzed C(sp3)?H aryl amination reaction is reported. Anthranil is employed as the nitrogen source with 100 % atom efficiency. This C?H amination reaction exhibits broad substrate scope without using any external oxidants. Mechanistic studies including rhodacycle intermediates, H–D exchange, kinetic isotope effect (KIE) experiments, and in situ IR are presented.