2067-33-6Relevant articles and documents
Organocatalyzed Aerobic Oxidation of Aldehydes to Acids
Dai, Peng-Fei,Qu, Jian-Ping,Kang, Yan-Biao
supporting information, p. 1393 - 1396 (2019/02/26)
The first example organocatalyzed aerobic oxidation of aldehydes to carboxylic acids in both organic solvent and water under mild conditions is developed. As low as 5 mol % N-hydroxyphthalimide was used as the organocatalyst, and molecular O2 was used as the sole oxidant. No transition metals or hazardous oxidants or cocatalysts were involved. A wide range of carboxylic acids bearing diverse functional groups were obtained from aldehydes, even from alcohols, in high yields.
A aldehyde or mellow directly converted into the carboxylic acid (by machine translation)
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Paragraph 0044-0046, (2018/08/03)
The invention discloses a aldehyde or mellow oxidation can be directly transformed into carboxylic acid, is characterized in that the pure oxygen environment, in N - hydroxy imide compound under the catalysis of the imide compound or N - hydroxy and nitrous acid ester compound common under the catalysis, the CH2 OH and CHO oxidation directly converted into the carboxylic acid compounds. The invention using oxygen as the oxidizing agent, does not add any metal catalyst, environment-friendly, high catalytic efficiency, simple and convenient operation. With the previous metal catalytic system complex and different catalytic system, has some metal catalytic system in the process, the use of transition metal will cause the transition metal of the residual, the invention adopts the non-metallic catalytic system, environmental protection, preventing the metal residue problem, this to the solution of the drug in the synthesis of transition metal residue problem and provides a new method of thinking. (by machine translation)
Preparation method of 5-bromo-valeric acid
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Paragraph 0097; 0098; 0099; 0100, (2016/11/28)
The invention relates to a preparation method of 5-bromo-valeric acid. The preparation method particularly includes: subjecting 5-chlorine-3-pentenoic acid ester to hydrolysis reaction, hydrogenation reaction and bromination reaction to obtain 5-bromo-valeric acid, wherein 5-chlorine-3-pentenoic acid ester is one of or multiple of 5-chlorine-3-pentenoic acid methyl ester, 5-chlorine-3-pentenoic acid ethyl ester, 5-chlorine-3-pentenoic acid propyl ester and 5-chlorine-3-pentenoic acid butyl ester. The preparation method is high in finished product yield, low in production cost, simple and easy to control and easy for industrial production, and using of high-toxicity substances like benzene and sodium cyanide is avoided, so that safety is high.