20699-85-8

Basic information

• Product Name: METHYL 5-AMINO-1-BENZOTHIOPHENE-2-CARBOXYLATE
• Synonyms: METHYL 5-AMINO-1-BENZOTHIOPHENE-2-CARBOXYLATE;ASISCHEM D48912;5-AMINO-BENZO[B]THIOPHENE-2-CARBOXYLIC ACID METHYL ESTER;methyl 5-aminobenzo[b]thiophene-2-carboxylate;5-Aminothionaphthene-2-carboxylic acid methyl ester;ethyl 5-aMinobenzo[b]thiophene-2-carboxylate;ethyl thieno[3,2-f]quinoline-2-carboxylate
• CAS NO: 20699-85-8
• Molecular Formula: C₁₀H₉NO₂S
• Molecular Weight: 207.25
• Mol File: 20699-85-8.mol
• Article Data: 11

Chemical Properties

• Melting Point: 178-179 ºC
• Boiling Point: 382.839 °C at 760 mmHg
• Flash Point: 185.334 °C
• Appearance: /
• Density: 1.353 g/cm³
• Vapor Pressure: 0mmHg at 25°C
• Refractive Index: 1.601
• Storage Temp.: under inert gas (nitrogen or Argon) at 2–8 °C
• PKA: 3.52±0.10(Predicted)
• CAS DataBase Reference: METHYL 5-AMINO-1-BENZOTHIOPHENE-2-CARBOXYLATE(CAS DataBase Reference)
• NIST Chemistry Reference: METHYL 5-AMINO-1-BENZOTHIOPHENE-2-CARBOXYLATE(20699-85-8)
• EPA Substance Registry System: METHYL 5-AMINO-1-BENZOTHIOPHENE-2-CARBOXYLATE(20699-85-8)

Safety Data

• Hazard Codes: Xn
• Statements: 20/21/22-36/37/38
• Safety Statements: 22-26-36/37/39
• Hazardous Substances Data: 20699-85-8(Hazardous Substances Data)

Usage

General Description

Methyl 5-amino-1-benzothiophene-2-carboxylate is a chemical compound with a molecular formula C12H11NO2S. It is a derivative of 1-benzothiophene, containing a methyl ester group at the 2-carboxylate position and an amino group at the 5-position. Methyl 5-amino-1-benzothiophene-2-carboxylate is commonly used as a building block in the synthesis of pharmaceuticals and agrochemicals. It has been studied for its potential pharmacological properties, including antiviral and anticancer activities. Additionally, its structural features make it a valuable intermediate for the development of new drugs and bioactive molecules. Despite its potential applications, Methyl 5-amino-1-benzothiophene-2-carboxylate should be handled and stored with care, as it may pose health and environmental hazards if mishandled.

InChI:InChI=1/C8H6BrNO2/c9-5-1-2-7-6(3-5)10-8(11)4-12-7/h1-3H,4H2,(H,10,11)

Upstream product

• 27996-87-8 2-fluoro-5-nitrobenzaldehye 
• 20699-86-9 methyl 5-nitrobenzo[b]thiophene-2-carboxylate 
• 6361-21-3 2-chloro-5-nitrobenzaldehyde 

Downstream Products

• 910791-67-2 5-phenylacetylamino-benzo[b]thiophene-2-carboxylic acid methyl ester 
• 910791-68-3 5-[2-(9H-fluoren-9-ylmethoxycarbonylamino)-3-phenyl-propionylamino]-benzo[b]thiophene-2-carboxylic acid methyl ester 
• 95094-87-4 5-hydroxy benzo[b]thiophene-2-carboxylic acid 
• 20532-43-8 methyl 5-(acetylamino)benzo[b]thiophene-2-carboxylate 
• 98589-46-9 5-aminobenzo[b]thiophene-2-carboxylic acid 
• 103566-21-8 5-(acetylamino)benzo[b]thiophene-2-carboxylic acid 
• 1160943-82-7 C₁₇H₁₃NO₃S 
• 1138154-46-7 C₂₆H₂₁N₃O₇S 
• 910791-71-8 5-[(2-benzyloxy-ethyl)-(3,3-dimethylbutyryl)-amino]-benzo[b]thiophene-2-carboxylic acid methyl ester 
• 910791-69-4 5-(2-amino-3-phenyl-propionylamino)-benzo[b]thiophene-2-carboxylic acid methyl ester 

Relevant articles and documents

METHOD FOR PROMOTING PLANT GROWTH

The present invention provides a method for promoting plant growth, which comprises treating a plant with at least one compound selected from a group consisting of a compound represented by the following Formula (1): and an agriculturally acceptable salt thereof, provided that a method for promoting plant growth which comprises treating plants with a compound corresponding to any one of the following (1) to (5) and an agriculturally acceptable salt thereof is excluded: (1) 4-(Trifluoromethyl)benzo[b]thiophene-2-carboxylic acid, (2) 5-(Trifluoromethyl)benzo[b]thiophene-2-carboxylic acid, (3) 6-(Trifluoromethyl)benzo[b]thiophene-2-carboxylic acid, (4) 7-(Trifluoromethyl)benzo[b]thiophene-2-carboxylic acid, and (5) Benzo[b]thiophene-2-carboxylic acid.

Hydroxybenzothiophene ketones are efficient pre-mRNA splicing modulators due to dual inhibition of Dyrk1A and Clk1/4

Dysregulated usage of pre-mRNA splicing sites contributes to the progression of cancer, neurodegenerative diseases, and viral infections. Serine/arginine-rich (SR) proteins play major roles in the splice site recognition and are largely regulated by phosp

PHENYL CARBOXAMIDE AND SULFONAMIDE DERIVATIVES FOR USE AS 11-BETA-HYDROXYSTEROID DEHYDROGENASE

There is provided a compound having Formula (I) R1-Z-R2 Formula (I) wherein R1 is an optionally substituted phenyl ring; R2 is or comprises an optionally substituted aromatic ring; and Z is -X-Y-L- or -Y-X-L- wherein either X is selected from -S(=O)(=O)- and -C(=O)-, and Y is -NR3-; or X is selected from -S(=O)(=O)- and -S-, and Y is -C(R4)(R5)-; L is an optional linker; and R3, R4 and R5 are each independently selected from H and hydrocarbyl; and wherein when R2 comprises the following structural moiety, Formula (II) wherein Q is an atom selected from the group consisting of S, O, N and C; the compound is selected from compounds of the formulae R1-C(=O)-NR3-L-R2; R1-S(=O)(=O)-C(R4)(R5)-L-R2; R1-S-C(R4)(R5)-L-R2; R1-NR3-S(=O)(=O)-L-R2; R1-NR3-C(=O)-L-R2; R1-C(R4)(R5)-S(=O)(=O)-L-R2; and R1-C(R4)(R5)-S-L-R2. These compounds are useful as 11β-hydroxysteriod dehydrogenase inhibitors in the treatment of i.a. diabetes.