20744-30-3

Basic information

• Product Name: 2,4-dimethoxy-α-phenoxyacetophenone
• Synonyms: 2,4-dimethoxy-α-phenoxyacetophenone
• CAS NO: 20744-30-3
• Molecular Weight: 272.301
• Mol File: 20744-30-3.mol
• Article Data: 2

Chemical Properties

• CAS DataBase Reference: 2,4-dimethoxy-α-phenoxyacetophenone(CAS DataBase Reference)
• NIST Chemistry Reference: 2,4-dimethoxy-α-phenoxyacetophenone(20744-30-3)
• EPA Substance Registry System: 2,4-dimethoxy-α-phenoxyacetophenone(20744-30-3)

Safety Data

• Hazardous Substances Data: 20744-30-3(Hazardous Substances Data)

Upstream product

• 77-78-1 dimethyl sulfate 
• 60965-26-6 2-Bromo-2',4'-dimethoxyacetophenone 
• 108-95-2 phenol 
• 701-99-5 Phenoxyacetyl chloride 
• 151-10-0 1,3-Dimethoxybenzene 

Downstream Products

• 829-20-9 2',4'-dimethoxyacetophenone 
• 613-45-6 2,4-Dimethoxybenzaldehyde 
• 108-95-2 phenol 

Relevant articles and documents

Identification of a Novel Oxadiazole Inhibitor of Mammalian Target of Rapamycin

We performed a biochemical screen against mTOR using in-house small molecule library. Two novel, structurally distinct hits were identified. Among them, a novel oxadiazole scaffold compound (2) suppressed the phosphorylation of both S6K1 and Akt1 in HeLa cells. Docking study suggested that 2 is ATP-competitive and shows a pi-pi interaction with Trp2239 and hydrogen bonds with Trp2239 and Thr2245. Through derivatization, a slightly more potent analogue (2a) was identified with IC50 of 9.6 μM. Our study provides a starting point for discovery of novel potent mTOR inhibitors.