207974-17-2

Basic information

• Product Name: 2,6-DIFLUOROPHENYL ISOTHIOCYANATE
• Synonyms: 2,6-DIFLUOROPHENYL ISOTHIOCYANATE;Benzene, 1,3-difluoro-2-isothiocyanato- (9CI);2,6-Difluorophenyl isothiocyanate 97%;2,6-Difluorophenylisothiocyanate97%;Benzene-1,3-difluoro-2-isothiocyanato;2,6-Difluorophenyl isothiocyanate,98%;2,6-Difluorophenyl isothiocyate
• CAS NO: 207974-17-2
• Molecular Formula: C₇H₃F₂NS
• Molecular Weight: 171.17
• EINECS: -0
• Product Categories: ISOTHIOCYANATE;Phenyl isocyanate&Phenyl isothiocyanate;Organic Building Blocks;Sulfur Compounds;Thiocyanates/Isothiocyanates;Fluorine series
• Mol File: 207974-17-2.mol
• Article Data: 6

Chemical Properties

• Boiling Point: 217 °C(lit.)
• Flash Point: 220 °F
• Appearance: /
• Density: 1.325 g/mL at 25 °C(lit.)
• Vapor Pressure: 1.21mmHg at 25°C
• Refractive Index: n20/D 1.604(lit.)
• Storage Temp.: 2-8°C
• Water Solubility: Hydrolyzes in water.
• Sensitive: Moisture Sensitive
• BRN: 2090586
• CAS DataBase Reference: 2,6-DIFLUOROPHENYL ISOTHIOCYANATE(CAS DataBase Reference)
• NIST Chemistry Reference: 2,6-DIFLUOROPHENYL ISOTHIOCYANATE(207974-17-2)
• EPA Substance Registry System: 2,6-DIFLUOROPHENYL ISOTHIOCYANATE(207974-17-2)

Safety Data

• Hazard Codes: C,T
• Statements: 34-42
• Safety Statements: 26-27-36/37/39-45
• RIDADR: UN 1760 8/PG 2
• WGK Germany: 3
• HazardClass: 6.1
• PackingGroup: II
• Hazardous Substances Data: 207974-17-2(Hazardous Substances Data)

Usage

Uses

2,6-Difluorophenyl isothiocyanate is used as chemical, organic and pharmaceutical intermediate.

General Description

2,6-Difluorophenyl isothiocyanate (1,3-Difluoro-2-isothiocyanatobenzene), an aryl isocyanate, can be prepared from difluoroaniline. 1H-[1,2,4]triazole-3,5-diamine undergoes acylation with 2,6-difluorophenyl isothiocyanate to form the corresponding 1-acyl-1H-[1,2,4]triazole-3,5-diamine.

InChI:InChI=1/C7H3F2NO/c8-5-2-1-3-6(9)7(5)10-4-11/h1-3H

Upstream product

• 463-71-8 thiophosgene 
• 5509-65-9 2,6-difluoroaniline 
• 16420-13-6 N,N-Dimethylthiocarbamoyl chloride 

Downstream Products

• 851749-68-3 sodium 3-cyano-1-(2, 6-difluorophenyl)-6-oxo-1,6-dihydropyridine-2-thiolate 
• 1207371-60-5 C₁₄H₁₁F₂N₃O₂S 
• 1192304-27-0 2'-O,3'-N-(carbonimidoyl)-3'-N-demethyl-N'-(2,6-difluorophenyl)-6-O-methyl-9a-aza-9a-homoerythromycin A 
• 1033590-93-0 C₁₄H₁₂F₂N₂OS 
• 1039819-74-3 3-(2,6-difluorophenyl)-4-oxo-2-thioxo-1,2,3,4-tetrahydroquinazoline 
• 1050542-53-4 C₁₆H₈F₂N₂OS₂ 
• 1050542-52-3 C₁₂H₆F₂N₂OS₂ 
• 611222-69-6 4-[2-(2,6-Difluoro-phenylamino)-1-methyl-1H-benzoimidazol-5-yloxy]-pyridine-2-carboxylic acid dimethylamide 
• 443798-55-8 3-amino-5-(4-sulfamoyl-phenylamino)-[1,2,4]triazole-1-carbothioic acid (2,6-difluoro-phenyl)-amide 
• 443798-47-8 CDK₁/2 inhibitor III 
• 1027266-81-4 1-(8-amino-4,4-dimethyl-1,3-dioxo-1,2,3,4-tetrahydro-isoquinolin-7-yl)-3-(2,6-difluoro-phenyl)-thiourea 
• 65295-73-0 1-(2-aminoethyl)-3-(2,6-difluorophenyl)-thiourea 

Relevant articles and documents

Synthesis and nematicidal activity of piperazinedione derivatives based on the natural product Barettin

Nematodes are serious constraints of crop production worldwide. However, the traditional nematicides suffer from the side-effects, including environmental and human toxicity. Herein, more than 70 novel piperazinedione derivatives based on the natural product Barettin were synthesized and evaluated against the root-knot nematode Meloidogyne incognita (M. incognita). While most of synthesized compounds exhibited certain nematicidal activity at high concentration, the best one showed a nematicidal activity of 75% at 2.4 μmol/L.

Thiazole-4-carboxyamide derivatives

The present invention is concerned with novel thiazole 4-carboxyamide derivatives of the general formula (I) and with methods for the preparation thereof, which compounds are useful as metabotropic glutamate receptor antagonists: wherein R1 to R4 are as defined in the specification.

Antihypertensive (2-Aminoethyl)thiourea Derivatives. 1

Structure-activity studies were carried out on a series of antihypertensive 1-(2-aminoethyl)-3-(substituted phenyl)thioureas.From this class of compounds, the 2,6-dichlorophenyl analogue 2 was found to have potent oral antihypertensive activity in two hypertensive rat models and the renal hypertensive dog.In addition to its effect on blood pressure, 2 displayed sedative effects which had a marked species specificity.