208122-09-2

Basic information

• Product Name: 2-amino-N-[4-cyano-3-(trifluoromethyl)phenyl]-2-methylpropanamide
• Synonyms: 2-amino-N-[4-cyano-3-(trifluoromethyl)phenyl]-2-methylpropanamide
• CAS NO: 208122-09-2
• Molecular Weight: 271.242
• Mol File: 208122-09-2.mol
• Article Data: 4

Chemical Properties

• CAS DataBase Reference: 2-amino-N-[4-cyano-3-(trifluoromethyl)phenyl]-2-methylpropanamide(CAS DataBase Reference)
• NIST Chemistry Reference: 2-amino-N-[4-cyano-3-(trifluoromethyl)phenyl]-2-methylpropanamide(208122-09-2)
• EPA Substance Registry System: 2-amino-N-[4-cyano-3-(trifluoromethyl)phenyl]-2-methylpropanamide(208122-09-2)

Safety Data

• Hazardous Substances Data: 208122-09-2(Hazardous Substances Data)

Upstream product

• 654-70-6 4-amino-2-trifluoromethylbenzonitrile 
• 1259327-69-9 2-bromo-N-(4-cyano-3-(trifluoromethyl)phenyl)-2-methylpropanamide 
• 94744-50-0 N-[(9H-fluoren-9-ylmethoxy)carbonyl]-α-aminoisobutyric acid 
• 30992-29-1 Boc-Aib-OH 

Downstream Products

• 143782-20-1 4-(4,4-dimethyl-2,5-dioxoimidazolidin-1-yl)-2-(trifluoromethyl)benzonitrile 
• 154992-24-2 4-[3-(4-hydroxybutyl)-4,4-dimethyl-2,5-dioxoimidazolidin-1-yl]-2-(trifluoromethyl)benzonitrile 
• 1802242-43-8 4-(3-(4-cyano-3-(trifluoromethyl)phenyl)-5,5-dimethyl-4-oxo-2-thioxoimidazolidin-1-yl)-2-fluorobenzoic acid methyl ester 
• 1289942-55-7 4-[1-(4-cyano-3-trifluoromethyl-phenylcarbamoyl)-1-methyl-ethylamino]-2-fluoro-N-methyl-benzamide 

Relevant articles and documents

Alternative synthesis of the anti-baldness compound RU58841

RU58841 is active against baldness and is commercially available. The previously reported synthesis uses phosgene, three discrete inert atmosphere steps and three steps that require flash chromatography. Our synthesis uses no phosgene, only one inert atmosphere step and does not require flash chromatography. This is achieved by stepwise construction of the hydantoin moiety around the amino group of 3-trifluoromethyl-4-cyanoaniline and ring closure to give a 2-nitropropane leaving group. On a small scale we achieved an overall yield of 33%.

Preparation method of enzalutamide of formula (VIII)

The invention discloses a preparation method of enzalutamide of formula (VIII). The method comprises the following steps: carrying out a condensation reaction on a compound of formula (I) and an aminoprotecting group PG-containing compound of formula (II) to produce a compound of formula (III); carrying out a protecting group PG removal reaction on the compound of formula (III) to form a compoundof formula (IV); carrying out a coupling reaction on the compound of formula (IV) and a compound of formula (V) at 25-160 DEG C to form a compound of formula (VI); and converting the compound of formula(VI-a) into a compound of formula (VII) when W is a C1-8 alkoxy group, and converting the compound of formula (VI-b) into into the compound of the formula (VIII) when the W is a methylamino group.The method has the advantages of high yield, omitting of the production of an intermediate isothiocyanate with poor stability, mild reaction conditions, simplicity in operation, and cheap and easily available reagents, is suitable for small-scale preparation in the laboratory, and is also suitable for large-scale industrial production.