208519-41-9

Basic information

• Product Name: 2-Chloro-6-hydroxymethyl-pyridin-3-ol
• Synonyms: 2-Chloro-6-hydroxymethyl-pyridin-3-ol
• CAS NO: 208519-41-9
• Molecular Formula: C₆H₆ClNO₂
• Molecular Weight: 159.57034
• Mol File: 208519-41-9.mol
• Article Data: 15

Chemical Properties

• Melting Point: 133～135℃
• Boiling Point: 407.6±40.0 °C(Predicted)
• Appearance: /
• Density: 1.493±0.06 g/cm3(Predicted)
• Storage Temp.: under inert gas (nitrogen or Argon) at 2-8°C
• PKA: 4.24±0.10(Predicted)
• CAS DataBase Reference: 2-Chloro-6-hydroxymethyl-pyridin-3-ol(CAS DataBase Reference)
• NIST Chemistry Reference: 2-Chloro-6-hydroxymethyl-pyridin-3-ol(208519-41-9)
• EPA Substance Registry System: 2-Chloro-6-hydroxymethyl-pyridin-3-ol(208519-41-9)

Safety Data

• Hazardous Substances Data: 208519-41-9(Hazardous Substances Data)

Usage

Description

2-Chloro-6-hydroxymethyl-pyridin-3-ol is an organic compound characterized by its chlorinated pyridine ring and hydroxymethyl group. It is a versatile chemical intermediate with potential applications in various fields due to its unique structural features and reactivity.

Uses

Used in Pharmaceutical Industry:
2-Chloro-6-hydroxymethyl-pyridin-3-ol is used as a key intermediate for the synthesis of various pharmaceutical compounds. Its unique structure allows for the development of novel drugs with specific therapeutic properties.
Used in HIV Treatment:
2-Chloro-6-hydroxymethyl-pyridin-3-ol is used as a reagent for the stereoselective preparation of furopyridylethylthiopyrimidine HIV-1 reverse transcriptase inhibitors. These inhibitors play a crucial role in the treatment of HIV by blocking the replication of the virus, thus helping to manage the progression of the disease.

Upstream product

• 6636-78-8 2-chloro-3-hydroxypyridine 
• 50-00-0 formaldehyd 

Downstream Products

• 1364677-04-2 6-chloro-4-(4-chlorophenyl)-5-(cyclopropylmethoxy)-2-pyridinemethanol 
• 1364676-96-9 6-chloro-4-(4-chlorophenyl)-5-(2,2,2-trifluoroethoxy)-2-pyridinemethanol 
• 1364677-06-4 4-(4-chlorophenyl)-5-(cyclopropylmethoxy)-2-pyridinemethanol 
• 1364676-98-1 4-(4-chlorophenyl)-5-(2,2,2-trifluoroethoxy)-2-pyridinemethanol 
• 1364677-08-6 4-(4-chlorophenyl)-5-(cyclopropylmethoxy)-2-pyridinecarboxylic acid 
• 1364677-00-8 4-(4-chlorophenyl)-5-(2,2,2-trifluoroethoxy)-2-pyridinecarboxylic acid 

Relevant articles and documents

TRICYCLIC PIPERIDINE COMPOUNDS

The present invention relates to compounds of the formula (I) wherein R1a, R1b, R2, R3, (R4)n and ring (A) are as described in the description, to their preparation, to pharmaceutically acc

TRICYCLIC PIPERIDINE COMPOUNDS

The present invention relates to compounds of the formula (I), wherein R, R1a, R1b, R2, R3, and X are as described in the description, to their preparation, to pharmaceutically acceptable salts thereof, and to their use as pharmaceuticals, to pharmaceutical compositions containing one or more compounds of formula (I), to methods for the preparation of such compounds of formula (I), and especially to their use as TPH modulators.

Modulators of S1P and Methods of Making And Using

The invention is directed to Compounds of Formula I: as well as methods of making and using the compounds.