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208761-39-1

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208761-39-1 Usage

Check Digit Verification of cas no

The CAS Registry Mumber 208761-39-1 includes 9 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 6 digits, 2,0,8,7,6 and 1 respectively; the second part has 2 digits, 3 and 9 respectively.
Calculate Digit Verification of CAS Registry Number 208761-39:
(8*2)+(7*0)+(6*8)+(5*7)+(4*6)+(3*1)+(2*3)+(1*9)=141
141 % 10 = 1
So 208761-39-1 is a valid CAS Registry Number.

208761-39-1Relevant articles and documents

Total synthesis of spirotryprostatin a, leading to the discovery of some biologically promising analogues

Edmondson, Scott,Danishefsky, Samuel J.,Sepp-Lorenzino, Laura,Rosen, Neal

, p. 2147 - 2155 (2007/10/03)

The total synthesis of the title compound has been accomplished. A key step involves the oxidative rearrangement of the β-carboline derivative to an oxindole via the action of N-bromosuccinimide. From this point, a diketopiperazine was introduced. A thiophenyl group served as a precursor of the isopropylidene function. Implementation of the same sort of chemistry starting with a methoxytryptophan derivative led to the parent structures. Furthermore, it was shown that the difficultly accessible isopropylidene side chain of spirotryprostatin A is not necessary for biological activity. Moreover, three analogues lacking the diketopiperazine system were shown to be quite active as cell cycle inhibitors.

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