20877-86-5

Basic information

• Product Name: 1-PHENYL-1H-BENZO[D][1,3]OXAZINE-2,4-DIONE
• Synonyms: 1-PHENYL-1H-BENZO[D][1,3]OXAZINE-2,4-DIONE
• CAS NO: 20877-86-5
• Molecular Formula: C₁₄H₉NO₃
• Molecular Weight: 239.23
• Mol File: 20877-86-5.mol
• Article Data: 14

Chemical Properties

• Appearance: /
• CAS DataBase Reference: 1-PHENYL-1H-BENZO[D][1,3]OXAZINE-2,4-DIONE(CAS DataBase Reference)
• NIST Chemistry Reference: 1-PHENYL-1H-BENZO[D][1,3]OXAZINE-2,4-DIONE(20877-86-5)
• EPA Substance Registry System: 1-PHENYL-1H-BENZO[D][1,3]OXAZINE-2,4-DIONE(20877-86-5)

Safety Data

• Hazardous Substances Data: 20877-86-5(Hazardous Substances Data)

Usage

Type

Synthetic chemical compound

Category

Organic

Common uses

Dye and pigment
Manufacturing of plastics
Inks and coatings
Textile industry (coloring fabrics)

Physical properties

Orange color
Belongs to the oxazine family

Potential health effects

Skin irritation, respiratory issues
May have harmful effects on aquatic organisms

Safety measures and precautions

Proper handling and disposal required to minimize risks

Upstream product

• 91-40-7 2-(phenylamino)benzoic acid 
• 541-41-3 chloroformic acid ethyl ester 
• 723-89-7 1-phenyl-indole-2,3-dione 
• 35708-19-1 Methyl N-phenylanthranilate 
• 503-38-8 trichloromethyl chloroformate 
• 118-48-9 isatoic anhydride 
• 603-33-8 triphenylbismuthane 
• 32315-10-9 bis(trichloromethyl) carbonate 
• 91-56-5 indole-2,3-dione 
• 108-86-1 bromobenzene 
• 75-44-5 phosgene 
• 16463-38-0 potassium 2-chlorobenzoate 
• 62-53-3 aniline 

Downstream Products

• 73480-74-7 [2-(5,6-Dihydro-4H-[1,3]oxazin-2-yl)-phenyl]-phenyl-amine 
• 1159216-52-0 2-methyl-N-phenyl-3-trimethylsilyl-4-quinolone 
• 1159216-66-6 2-methyl-3,N-diphenyl-4-quinolone 
• 200406-19-5 3-methyl-2,N-diphenyl-4-quinolone 
• 1159216-71-3 3-methyl-2-pentyl-N-phenyl-4-quinolone 
• 1159216-38-2 2-methyl-3-pentyl-N-phenyl-4-quinolone 
• 1159216-43-9 2-methyl-N-phenyl-3-sec-propyl-4-quinolone 
• 1159216-75-7 3-methyl-N-phenyl-3-sec-propyl-4-quinolone 
• 1159216-61-1 N-phenyl-2-(2-propenyl)-3-trimethylsilyl-4-quinolone 
• 1159216-28-0 1,2,3-triphenylquinolin-4(1H)-one 
• 1261594-11-9 1-phenyl-3-benzyl-3,4-dihydro-1H-benzo[d][1,3]diazepine-5(2H)-one 
• 1411642-24-4 5,11-diphenyl-6-(trifluoromethyl)-12-[(trimethylsilyl)oxy]-5,6,11,12-tetrahydro-6,12-epoxydi-benzo[b,f][1,5]diazocine 
• 1450619-89-2 10-phenyl-1,3,4,4a,9a,10-hexahydro-1,4-methanoacridin-9(2H)-one 
• 54879-94-6 N-phenyl-2,3-diphenylindole 

Relevant articles and documents

Synthesis of Ring-Fused, N-Substituted 4-Quinolinones Using p Ka-Guided, Base-Promoted Annulations with Isatoic Anhydrides: Total Synthesis of Penicinotam

An anionic annulation strategy employing isatoic anhydrides and a wide assortment of enolizable partners was developed to afford over 80 novel ring-fused, N-substituted 4-quinolinones, an underrepresented privileged template. Multiple factors governing the efficiency of the transformation were determined, resulting in a reliable and tunable synthetic platform applicable for a broad range of substrates with variable deprotonation susceptibility, such as tetramic and tetronic acids, cyclic 1,3-diketones, and cycloalkanones. Application to the synthesis of bioactive, pyrrolizine-fused 4-quinolinone, penicinotam 3, resulted in the most brief and highest yielding total synthesis of the alkaloid in three steps and a 36% overall yield.

Synthesis of methyl 2-[(1,2-dihydro-4-hydroxy-2-oxo-1-phenylquinolin-3-yl) carbonylamino] alkanoates and methyl 2-[2-((1,2-dihydro-4-hydroxy-2-oxo-1-phenylquinolin-3-yl)carbonyl-amino)alkanamido] alkanoate

A series of methyl 2-[(1,2-dihydro-4-hydroxy-2-oxo-1-phenylquinolin-3-yl)carbonylamino] alkanoates 7a-f has been developed by the direct condensation of ethyl [4-hydroxy-2-oxo-1-phenyl-1,2-dihydro-3-quinoline] carboxylate 4 with amino acid ester hydrochloride in the presence of triethylamine. The quinoline amino acid esters 7a-f were the key intermediate for the preparation of a series of methyl 2-[2-((1,2-dihydro-4-hydroxy-2-oxo-1-phenylquinolin-3-yl)carbonylamino)alkanamido] alkanoate 10-13(a-f) via azide coupling method with amino acid ester. {figure presented}.

Isatoic anhydride and its process for synthesis of derivatives of

The invention discloses a synthesis method of isatoic anhydride and a derivative thereof, relating to the technical field of chemical synthesis. In the presence of catalysis of an organic selenium catalyst, isatin or a derivative thereof is oxidized by using hydrogen peroxide to prepare the isatoic anhydride and the derivative thereof. The synthesis method disclosed by the invention is simple and easily available in raw materials, low in cost, clean in oxidizing agent, free from a metal catalyst, and environmentally friendly, can be carried out in a neutral environment, and is small in corrosion to equipment.