209002-03-9

Basic information

• Product Name: 1H-PYRAZOLE-3-CARBALDEHYDE
• CAS NO: 209002-03-9
• Molecular Formula: C4H4N2O
• Molecular Weight: 96.08736
• EINECS: -0
• Mol File: 209002-03-9.mol
• Article Data: 6

Chemical Properties

• Appearance: /
• CAS DataBase Reference: 1H-PYRAZOLE-3-CARBALDEHYDE(CAS DataBase Reference)
• NIST Chemistry Reference: 1H-PYRAZOLE-3-CARBALDEHYDE(209002-03-9)
• EPA Substance Registry System: 1H-PYRAZOLE-3-CARBALDEHYDE(209002-03-9)

Safety Data

• Hazardous Substances Data: 209002-03-9(Hazardous Substances Data)

Usage

Description

1H-Pyrazole-3-carbaldehyde is a heterocyclic organic compound with a molecular formula C4H4N2O. It features a pyrazole ring and an aldehyde group, making it a versatile intermediate in the synthesis of various biologically active molecules. Widely used in medicinal chemistry and drug development, this compound serves as a key building block for creating pharmaceuticals, agrochemicals, and other organic compounds.

Uses

Used in Pharmaceutical Industry:
1H-Pyrazole-3-carbaldehyde is used as a key intermediate for the synthesis of various pharmaceuticals. Its aldehyde group allows for the creation of a wide range of functionalized derivatives, which can be further utilized in the development of new drugs with potential therapeutic applications.
Used in Agrochemical Industry:
In the agrochemical sector, 1H-Pyrazole-3-carbaldehyde is employed as a precursor in the synthesis of agrochemicals. Its ability to form diverse derivatives makes it a valuable component in the development of pesticides, herbicides, and other agricultural chemicals that can improve crop yields and protect plants from pests.
Used in Organic Chemistry:
1H-Pyrazole-3-carbaldehyde is utilized as a versatile reagent in organic chemistry. Its pyrazole ring and aldehyde group enable the synthesis of a variety of complex organic compounds, which can be applied across different industries, including materials science, chemical research, and the development of new technologies.

Upstream product

• 186581-53-3 diazomethane 
• 624-67-9 Propargylic aldehyde 
• 111573-59-2 pyrazole-3-carboxaldehyde dimethylacetal 
• 23585-49-1 (1H-pyrazol-3-yl)methanol 

Downstream Products

• 397329-07-6 1-allyl-1H-pyrazole-3-carbaldehyde 
• 40261-59-4 1-Phenyl-1H-pyrazole-3-carbaldehyde 
• 1259224-01-5 4-iodo-1H-pyrazole-3-carbaldehyde 
• 27258-32-8 1-methyl-1H-pyrazole-3-carbaldehyde 

Relevant articles and documents

Optimization and biological evaluation of 2-aminobenzothiazole derivatives as Aurora B kinase inhibitors

A strong relationship between abnormal functions of Aurora kinases and tumorigenesis has been reported for decades. Consequently, Aurora kinases serve as potential targets for anticancer agents. Here, we identified aminobenzothiazole derivatives as novel inhibitors of Aurora B kinase through bioisosteric replacement of the previous inhibitors, aminobenzoxazole derivatives. Most of the urea-linked aminobenzothiazole derivatives showed potent and selective inhibitory activity against Aurora B kinase over Aurora A kinase. Molecular modeling indicated that compound 15g bound well to the active site of Aurora B kinase and formed the essential hydrogen bonds. The potent compounds, 15g and 15k, were selected, and their biological effects were evaluated using HeLa cell lines. It was found that these compounds inhibited the phosphorylation of histone H3 at Ser10 and induced G2/M cell cycle arrest. We suggest that the reported compounds have the potential to be further developed as anticancer therapeutics.

Highly active binuclear Cu(II) catalyst bearing an unsymmetrical bipyridine-pyrazole-amine ligand for the azide-alkyne cycloaddition reaction

Ligands containing NH groups often show special characteristics. In this paper, a well-defined dinuclear Cu(II) complex bearing an unsymmetrical bipyridine-pyrazole-amine ligand was synthesized by the condensation of N–H to release H2O. Using sodium L-ascorbate as a reductant, the binuclear complex showed excellent activity in 1,3-dipolar cycloaddition reactions between alkynes and azides to obtain 1,4-disubstituted triazoles in 95%–99% isolated yields.

Acetylenic 1,5-diarylpyrazoles as antiinflammatory agents

Compounds of Formula I STR1 wherein, R1 through R7 are described herein. These compounds inhibit the production of arachidonic acid products associated with 5-lipoxygenase and cyclooxygenase and are useful in the treatment of inflamm