20922-60-5Relevant articles and documents
Selective Gold-Catalysed Synthesis of Cyanamides and 1-Substituted 1H-Tetrazol-5-Amines from Isocyanides
?koch, Karel,Císa?ová, Ivana,?těpni?ka, Petr
supporting information, p. 13788 - 13791 (2018/09/14)
The newly discovered gold-catalysed reaction of isocyanides with hydrazoic acid generated in situ from trimethylsilyl azide and methanol (or, alternatively, from NaN3/AcOH) produces either cyanamides or 1-substituted 1H-tetrazol-5-amines, depending on the amount of available HN3. The reaction proceeds selectively and in generally high yields of either product, thus providing a particularly convenient access to a wide range of substituted 1H-tetrazol-5-amines that are rather difficult to access otherwise.
A convenient syntheses of some new substituted guanidines
Ahmad, S. S.,Haider, S. I.,Fatima, I.
, p. 1861 - 1864 (2007/10/02)
The cyanamides of 2,6-dimethylaniline, N-methyl-α, β-naphthylamines, 2-methylpiperidine and indoline yielded their respective guanido derivatives on treatment with dry ammonia and their structures have been characterized through spectral studies.
Novel 2,6-di-substituted phenyl-aminoquanidine containing compositions and methods of using same and pharmaceutical compositions containing the same and therapeutic method
-
, (2008/06/13)
The invention relates to compounds of the general formula: STR1 in which one double bond is present between the carbon atom of the quanidine moiety and one of the adjacent nitrogen atoms and R0 stands for hydrogen, halogen, hydroxy, alkoxy or alkyl (1 to 6 C), R1, r2 for halogen, hydroxy, alkyl (1 to 4 C) or alkoxy (1 to 4 C), R3, r3 ', r3 " for hydrogen or alkyl (1 to 4 C), on the understanding that one of the substituents R3, R3 ' or R3 " is absent because of the presence of the double bond, R4 for hydrogen, alkyl (1-4 C), hydroxy, alkoxy (1-4 C) or amino optionally substituted with one or two alkyl (1 to 4 C) groups, R5, r6 for hydrogen, alkyl (1-6 C), acyl or R5 + R6 together represent an alkylidene, cyclic alkylidene or aralkylidene group, as well as the acid addition salts thereof, Provided that, if R4 stands for methyl and R0, R3, R3 ", R5 and R6 for hydrogen, R1 and R2 may not represent methyl simultaneously, having a strong and long-acting anti-hypertensive activity.