209252-16-4

Basic information

• Product Name: Fmoc-D-beta-homophenylalanine
• Synonyms: Fmoc-(R)-3-Amino-4-phenylpropionic acid;FMOC--3-AMINO-4-PHENYLPROPIONIC ACID;Fmoc-D-b-HoPhe-OH;(R)-3-(9H-Fluoren-9-ylmethoxycarbonylamino)-4-phenylbutyric acid;(R)-3-(Fmoc-amino)-4-phenylbutyric acid, Fmoc-D-β-homophenylalanine;Fmoc-D-beta-homophenylalan;Fmoc-D-Beta-homo-Phe;Fmoc-D-beta-homophenylalanine
• CAS NO: 209252-16-4
• Molecular Formula: C₂₅H₂₃NO₄
• Molecular Weight: 401.45
• Mol File: 209252-16-4.mol
• Article Data: 3

Chemical Properties

• Boiling Point: 633.2 °C at 760 mmHg
• Flash Point: 336.8 °C
• Appearance: /
• Density: 1.254 g/cm³
• Vapor Pressure: 6.64E-17mmHg at 25°C
• Refractive Index: 1.624
• Storage Temp.: 2-8°C
• PKA: 4.38±0.10(Predicted)
• CAS DataBase Reference: Fmoc-D-beta-homophenylalanine(CAS DataBase Reference)
• NIST Chemistry Reference: Fmoc-D-beta-homophenylalanine(209252-16-4)
• EPA Substance Registry System: Fmoc-D-beta-homophenylalanine(209252-16-4)

Safety Data

• WGK Germany: 3
• F: 10-21
• Hazardous Substances Data: 209252-16-4(Hazardous Substances Data)

Usage

Uses

Fmoc-d-beta-homophenylalanine

InChI:InChI=1/C25H23NO4/c27-24(28)15-18(14-17-8-2-1-3-9-17)26-25(29)30-16-23-21-12-6-4-10-19(21)20-11-5-7-13-22(20)23/h1-13,18,23H,14-16H2,(H,26,29)(H,27,28)

Upstream product

• 86123-10-6 Fmoc-D-Phe-OH 
• 203854-65-3 ((R)-1-Benzyl-3-diazo-2-oxo-propyl)-carbamic acid 9H-fluoren-9-ylmethyl ester 

Relevant articles and documents

Synthesis of β-amino acids: 2-(1H-benzotriazol-1-yl)-1,1,3,3-tetramethyl-uronium tetrafluoroborate (TBTU) for activation of Fmoc-/Boc-/Z-α-amino acids

A new and efficient method for the homologation of urethane protected α-amino acids to its β-homomers by the Arndt-Eistert method using TBTU as a coupling agent is described. Several Fmoc-/Boc-/Z-protected α-amino diazoketone derivatives have been obtaine

Synthesis of Fmoc-β-homoamino acids by ultrasound-promoted wolff rearrangement

A highly efficient protocol for Amdt-Eistert chain elongation of the base-labile fluorenylmethoxycarbonyl (Fmoc) protected α-amino acids by Ag+- catalyzed, ultrasound-promoted Wolff rearrangement of the corresponding α- diazo ketones at room temperature is described. The enantiomeric purity of the products was examined by capillary zone electrophoresis with chiral buffer systems.