20998-83-8

Basic information

• Product Name: Carbamic acid, [(1S)-2-methyl-1-[[(phenylmethyl)amino]carbonyl]propyl]-, phenylmethyl ester
• Synonyms: Z-Val-NH-CH2-C6H5;benzyl (S)-N-(1-benzylcarbamoyl-2-methylpropyl)carbamate;N-BENZYLOXYCARBONYL-L-VALINE BENZYLAMIDE,;1-benzylcarbamoyl -2-methyl-propyl-carbamic acid bezyl ester;Benzyloxycarbonyl-L-valin-benzylamid;N-benzyloxycarbonyl-L-valine benzylamide;((S)-1-Benzylcarbamoyl-2-methyl-propyl)-carbamic acid benzyl ester
• CAS NO: 20998-83-8
• Molecular Formula: C20H24N2O3
• Molecular Weight: 340.422
• Mol File: 20998-83-8.mol
• Article Data: 9

Chemical Properties

• CAS DataBase Reference: Carbamic acid, [(1S)-2-methyl-1-[[(phenylmethyl)amino]carbonyl]propyl]-, phenylmethyl ester(CAS DataBase Reference)
• NIST Chemistry Reference: Carbamic acid, [(1S)-2-methyl-1-[[(phenylmethyl)amino]carbonyl]propyl]-, phenylmethyl ester(20998-83-8)
• EPA Substance Registry System: Carbamic acid, [(1S)-2-methyl-1-[[(phenylmethyl)amino]carbonyl]propyl]-, phenylmethyl ester(20998-83-8)

Safety Data

• Hazardous Substances Data: 20998-83-8(Hazardous Substances Data)

Upstream product

• 1149-26-4 (S)-N-(benzyloxycarbonyl)valine 
• 73504-31-1 benzyloxycarbonylamino 3-butyric acid benzyl ester 
• 100-46-9 benzylamine 
• 3496-11-5 2,5-dioxopyrrolidin-1-yl (2S)-2-(((benzyloxy)carbonyl)amino)-3-methylbutanoate 

Downstream Products

• 137271-89-7 N-((2-hydroxy-1-naphthyl)methylene)-(S)-valine benzylamide 
• 106566-02-3 L-valine benzylamide 

Relevant articles and documents

Mechanistic implications of the enantioselective addition of alkylzinc reagents to aldehydes catalyzed by nickel complexes with α-amino amide ligands

The enantioselective alkylation of aldehydes catalysed by nickel(ii)-complexes derived from α-amino amides was studied by means of density functional theory (DFT) and ONIOM (B3LYP:UFF) calculations. A mechanism was proposed in order to investigate the origin of enantioselectivity. The chirality-determining step for the alkylation was the formation of the intermediate complexes with the involvement of a 5/4/4-fused tricyclic transition state. The predominant products predicted theoretically were of (S)-configuration, in good agreement with experimental observations. The scope of the reaction was examined and high yields and enantioselectivities were observed for the enantioselective addition of Et2Zn and Me2Zn to aromatic and aliphatic aldehydes.

C2 symmetrical nickel complexes derived from α-amino amides as efficient catalysts for the enantioselective addition of dialkylzinc reagents to aldehydes

A series of C2 symmetrical 1:2 Ni:L complexes derived from α-amino amides were studied for the enantioselective addition of dialkylzinc reagents to aldehydes. Different structural elements on the ligands seem to play an important role in determining the observed enantioselectivity. Through optimization of structure and reaction conditions, the best ligand provided secondary alcohols in excellent yields (up to 98%) and enantioselectivity of up to 99% ee for (R)-enantiomer. A transition state model has been proposed to explain the observed enantioselectivities based on computational calculations at the DFT level. Very interestingly, calculations suggest a coordination model of the aldehyde to the metal complex through association of a lone pair of the carbonyl oxygen to the hydrogen atom of an amino group.

Catalyst and solvent-free amidation of inactive esters of N-protected amino acids

A catalyst free procedure for the preparation of amides from inactive esters of N-protected amino acids and various amines is demonstrated under mild reaction conditions. Our effort to recover excess amine and generated alcohol is an approach towards environment friendly and cost effective synthesis under easy operational conditions.