210344-92-6

Basic information

• Product Name: Z-VDVAD-FMK
• Synonyms: BENZYLOXYCARBONYL-VAL-ASP(OME)-VAL-ALA-ASP(OME)-FLUOROMETHYLKETONE;CASPASE-2 INHIBITOR I;Z-VAL-ASP-VAL-ALA-ASP-FLUOROMETHYLKETONE;Z-VAL-ASP(OME)-VAL-ALA-ASP(OME)-FLUOROMETHYLKETONE;Z-VAL-ASP(OME)-VAL-ALA-ASP(OME)-FMK;Z-VAL-ASP(OME)-VAL-ALA-DL-ASP(OME)-FLUOROMETHYLKETONE;Z-VDVAD-FLUOROMETHYLKETONE;Z-VDVAD-FMK
• CAS NO: 210344-92-6
• Molecular Formula: C32H46FN5O11
• Molecular Weight: 695.73
• Product Categories: Caspases/Apoptosis;Caspase/Related Products
• Mol File: 210344-92-6.mol
• Article Data: 0

Chemical Properties

• Appearance: white/powder
• Storage Temp.: −20°C
• Solubility: DMSO/DMF: 20 mM
• CAS DataBase Reference: Z-VDVAD-FMK(CAS DataBase Reference)
• NIST Chemistry Reference: Z-VDVAD-FMK(210344-92-6)
• EPA Substance Registry System: Z-VDVAD-FMK(210344-92-6)

Safety Data

• WGK Germany: 3
• Hazardous Substances Data: 210344-92-6(Hazardous Substances Data)

Usage

Biological Activity

Irreversible caspase-2 inhibitor. Attenuates oxyhemoglobin-induced cleavage of PARP and apoptosis in endothelial cells.

Biochem/physiol Actions

A cell-permeable inhibitor of caspase-2, which exhibits competitive and irreversible inhibition.

references

1. j. d. robertson, m. enoksson et al. caspase-2 acts upstream of mitochondria to promote cytochrome c release during etoposide-induced apoptosis. the journal of biological chemistry. 277, :29803–29809, 2002 2. t. meguro, b. chen et al. caspase inhibitors attenuate oxyhemoglobin-induced apoptosis in endothelial cells, stroke. 2001; 32:561-566. 3. talanian, r. v., quinlan, c., trautz, s., hackett, m. c., mankovich, j. a., banach, d., ghayur, t., brady, k. d., and wong, w. w. (1997). substrate speci?city of caspase family proteases. j. biol. chem. 272, 9677–9682. 4. gamen et al (2000) doxorubicin treatment activates a z-vad-sensitive caspase, which causes dym loss, caspase-9 activity, and apoptosis in jurkat cells. exp.cell res. 258 223.