210542-62-4

Basic information

• Product Name: 5-Cyclohexyl-1,1,1-trifluoro-pentan-2-one
• Synonyms: 5-Cyclohexyl-1,1,1-trifluoro-pentan-2-one
• CAS NO: 210542-62-4
• Molecular Weight: 222.251
• Mol File: 210542-62-4.mol
• Article Data: 1

Chemical Properties

• CAS DataBase Reference: 5-Cyclohexyl-1,1,1-trifluoro-pentan-2-one(CAS DataBase Reference)
• NIST Chemistry Reference: 5-Cyclohexyl-1,1,1-trifluoro-pentan-2-one(210542-62-4)
• EPA Substance Registry System: 5-Cyclohexyl-1,1,1-trifluoro-pentan-2-one(210542-62-4)

Safety Data

• Hazardous Substances Data: 210542-62-4(Hazardous Substances Data)

Upstream product

• 383-63-1 ethyl trifluoroacetate, 
• 62638-00-0 lithium 4-cyclo-hexylbutyrate 

Downstream Products

• 1401112-33-1 1-chloro-9-cyclohexyl-6-(trifluoromethyl)non-5-en-2-one 
• 1401112-34-2 1-chloro-9-cyclohexyl-6-(trifluoromethyl)non-5-en-2-one 
• 1401112-25-1 N-(4-bromophenyl)-8-cyclohexyl-N-(methylsulfonyl)-5-(trifluoromethyl)oct-4-enamide 
• 1401112-26-2 N-(4-bromophenyl)-8-cyclohexyl-N-(methylsulfonyl)-5-(trifluoromethyl)oct-4-enamide 
• 1401112-19-3 3-(6-cyclohexyl-3-(trifluoromethyl)hex-2-en-1-yl)-1-tosylpiperidin-4-one 
• 1401112-20-6 3-(6-cyclohexyl-3-(trifluoromethyl)hex-2-en-1-yl)-1-tosylpiperidin-4-one 
• 1401112-72-8 2-((6-cyclohexyl-3-(trifluoromethyl)hex-1-en-3-yl)oxy)-6-fluoropyridine 
• 1401112-73-9 C₁₃H₂₁F₃O 

Relevant articles and documents

Trifluoromethyl ketones from enolizable carboxylic acids via enediolate trifluoroacetylation/decarboxylation

(Chemical Equation Presented) Primary and secondary (enolizable) carboxylic acids were converted in a single step to trifluoromethyl ketones. Treatment of the acid with 2.2 equiv of LDA generated an enediolate that was trifluoroacetylated with EtO2CCF3. Quenching the reaction mixture with aqueous HCl resulted in rapid decarboxylation and provided the trifluoromethyl ketone product in good yield. The process may be performed at -20°C with a slight reduction in yield. The reaction was extended to the preparation of pentafluoroethyl and chlorodifluoromethyl ketones.