210687-17-5Relevant articles and documents
Synthesis of (25R)-5α-Cholestane-3β,6β,15α,16β,26-pentol, a Cytostatic Starfish Steroid1
Izzo, Irene,De Riccardis, Francesco,Sodano, Guido
, p. 4438 - 4443 (2007/10/03)
The synthesis of (25R)-5αa-cholestane-3β,6β 15α,16β,26-pentol (1a), a marine cytostatic steroid, has been achieved in 13 steps (7.8% overall yield) starting from commercially available diosgenin (2). A key step in the synthesis was the dimethyldioxirane oxidation of the enolsilane 16 to introduce the 15α-hydroxy group in the D ring.