210699-97-1Relevant articles and documents
Evaluation and Development of Practical Routes to an Enantiomerically Pure C 2-Symmetric Diamine Building Block
Karlsson, Staffan,Lindberg, Jan,Soerensen, Henrik
, p. 1552 - 1560 (2013)
Several routes to an enantiomerically pure C2-symmetric diamine were evaluated and modified to scalable methods. A Zn/Me3SiCl- mediated reductive coupling of an imine was found to be superior to the other methods investigated, allowing us to safely prepare the enantiomerically pure diamine also on a large scale. One key step in this method was a highly efficient resolution of a stereoisomeric mixture of the diamine through salt formation with (-)-dibenzoyl-l-tartaric acid. The enantiomerically pure C 2-symmetric diamine obtained was further used as a key building block for the synthesis of potent Kv1.5 channel blockers.
Formation of 2,4,5-triaryl-4,5-dihydro-1H-imidazoles, (1), from aryl aldehydes. Crystal structures of cis-(1: aryl = pyridin-2-yl), {trans-[(1: aryl = pyridin-2-yl)H]+[OAc]-·3H2O}, {cis-[1: aryl = thien-2-yl]·0.5H2O} and trans-(1: aryl = thien-2-yl)
Fernandes, Christiane,Horn Jr., Adolfo,Howie, R. Alan,Schripsema, Jan,Skakle, Janet M.S.,Wardell, James L.
, p. 274 - 283 (2007/10/03)
The preparations of cis-2,4,5-triaryl-4,5-dihydro-1H-imidazoles, (aryl = thien-2-yl or pyridin-2-yl) from aryl aldehydes, ammonium chloride and triethylamine in methanol, and their conversions to the trans-isomers are reported. Crystal structures of cis-(1: aryl = pyridin-2-yl), cis-[1: aryl = thien-2-yl·0.5H2O], trans-(1: aryl = thien-2-yl), and trans-{[(1: aryl = pyridin-2-yl)H]+[OAc]-·3H2O}, have been determined and compared with related structures.
