2108-54-5

Basic information

• Product Name: 1-(4-METHOXY-PHENYL)-PENTANE-1,4-DIONE
• Synonyms: 1-(4-METHOXY-PHENYL)-PENTANE-1,4-DIONE;1-(1,4-Dioxopentyl)-4-methoxybenzene
• CAS NO: 2108-54-5
• Molecular Formula: C₁₂H₁₄O₃
• Molecular Weight: 206.23776
• Mol File: 2108-54-5.mol
• Article Data: 34

Chemical Properties

• Melting Point: 56.5-57 °C
• Boiling Point: 102 °C(Press: 0.80 Torr)
• Appearance: /
• Density: 1.076±0.06 g/cm3(Predicted)
• CAS DataBase Reference: 1-(4-METHOXY-PHENYL)-PENTANE-1,4-DIONE(CAS DataBase Reference)
• NIST Chemistry Reference: 1-(4-METHOXY-PHENYL)-PENTANE-1,4-DIONE(2108-54-5)
• EPA Substance Registry System: 1-(4-METHOXY-PHENYL)-PENTANE-1,4-DIONE(2108-54-5)

Safety Data

• Hazardous Substances Data: 2108-54-5(Hazardous Substances Data)

Usage

Synthesis Reference(s)

The Journal of Organic Chemistry, 56, p. 5774, 1991 DOI: 10.1021/jo00020a015

Upstream product

• 1490-24-0 4-oxo-pentanoyl chloride 
• 100-66-3 methoxybenzene 
• 4996-51-4 dimethyl-(2-nitro-propenyl)-amine 
• 100-06-1 1-(4-methoxyphenyl)ethanone 
• 100-07-2 4-methoxy-benzoyl chloride 
• 78-94-4 methyl vinyl ketone 
• 135468-06-3 1-(p-methoxyphenyl)pent-2-yne-1,4-diol 
• 123-76-2 levulinic acid 
• 201230-82-2 carbon monoxide 
• 2227-57-8 3-(4-methoxyphenyl)propynoic acid 
• 67-64-1 acetone 
• 15482-28-7 2-hydroxy-1-(4-methoxyphenyl)-propan-1-one 
• 42435-77-8 S-ethyl 4-oxopentanethioate 
• 1833-53-0 2-(Trimethylsilyloxy)propene 

Downstream Products

• 3319-15-1 rac-1-(4-methoxyphenyl)-ethanol 
• 62154-11-4 2,3-bis(4-methoxyphenyl)butane-2,3-diol 
• 100-06-1 1-(4-methoxyphenyl)ethanone 
• 123184-59-8 3-[2-(4-Methoxy-phenyl)-5-methyl-pyrrol-1-yl]-propionaldehyde 
• 123185-31-9 (4R,6R)-4-Hydroxy-6-{2-[2-(4-hydroxy-phenyl)-5-methyl-pyrrol-1-yl]-ethyl}-tetrahydro-pyran-2-one 
• 104568-78-7 (4R,6R)-4-Hydroxy-6-{2-[2-(4-methoxy-phenyl)-5-methyl-pyrrol-1-yl]-ethyl}-tetrahydro-pyran-2-one 
• 376636-85-0 1-(4-bromophenyl)-2-(4-methoxyphenyl)-5-methyl-1H-pyrrole 
• 61363-17-5 2-(4-methoxyphenyl)-5-methyl-1-phenyl-1H-pyrrole 
• 1609193-02-3 (R)-5-methyl-2-(4-methoxyphenyl)-1-pyrroline 
• 882973-53-7 (2S,5R)-2-(4-methoxyphenyl)-5-methylpyrrolidine 
• 1609193-10-3 (2S,5S)-2-(4-methoxyphenyl)-5-methylpyrrolidine 
• 1609192-83-7 (S)-5-methyl-2-(4-methoxyphenyl)-1-pyrroline 
• 1458715-58-6 5,6,7-trimethoxy-2-(4-(2-(4-methoxyphenyl)-5-methyl-1H-pyrrol-1-yl)phenyl)benzo[d]thiazole 
• 1458715-52-0 6-methoxy-2-(4-(2-(4-methoxyphenyl)-5-methyl-1H-pyrrol-1-yl)phenyl)benzo[d]thiazole 

Relevant articles and documents

1,3-Alkyl Transposition in Allylic Alcohols Enabled by Proton-Coupled Electron Transfer

A method is described for the isomerization of acyclic allylic alcohols into β-functionalized ketones via 1,3-alkyl transposition. This reaction proceeds via light-driven proton-coupled electron transfer (PCET) activation of the O?H bond in the allylic al

A fluorescent target-guided Paal-Knorr reaction

It has become increasingly apparent that high-diversity chemical reactions play a significant role in the discovery of bioactive small molecules. Here, we describe an expanse of this paradigm, combining a ‘target-guided synthesis’ concept with Paal-Knorr chemistry applied to the preparation of fluorescent ligands for human prostaglandin-endoperoxide synthase (COX-2).

Nickel-Catalyzed Coupling of Arylzinc Halides with Thioesters

The Pd-catalyzed Fukuyama reaction of thioesters with organozinc reagents is a mild, functional-group-tolerant method for acylation chemistry. Its Ni-catalyzed variant might be a sustainable alternative to expensive catalytic Pd sources. We investigated the reaction of S-ethyl thioesters with aryl zinc halides with hetero- and homotopic Ni precatalysts and several ligands. The results show that both homo- and heterotopic species may contribute to catalysis. The substrate scope using an operationally homogeneous defined Ni complex was established. Acyl radicals are postulated as short-lived intermediates.