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213133-77-8

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213133-77-8 Usage

Chemical Properties

White crystals

Check Digit Verification of cas no

The CAS Registry Mumber 213133-77-8 includes 9 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 6 digits, 2,1,3,1,3 and 3 respectively; the second part has 2 digits, 7 and 7 respectively.
Calculate Digit Verification of CAS Registry Number 213133-77:
(8*2)+(7*1)+(6*3)+(5*1)+(4*3)+(3*3)+(2*7)+(1*7)=88
88 % 10 = 8
So 213133-77-8 is a valid CAS Registry Number.
InChI:InChI=1/C9H8BrFO/c1-2-9(12)6-3-7(10)5-8(11)4-6/h3-5H,2H2,1H3

213133-77-8SDS

SAFETY DATA SHEETS

According to Globally Harmonized System of Classification and Labelling of Chemicals (GHS) - Sixth revised edition

Version: 1.0

Creation Date: Aug 15, 2017

Revision Date: Aug 15, 2017

1.Identification

1.1 GHS Product identifier

Product name 2-[(3,4-dichlorophenyl)methyl]-1H-benzimidazole

1.2 Other means of identification

Product number -
Other names 2-(3,4-Dichlorobenzyl)-1H-benzo[d]imidazole

1.3 Recommended use of the chemical and restrictions on use

Identified uses For industry use only.
Uses advised against no data available

1.4 Supplier's details

1.5 Emergency phone number

Emergency phone number -
Service hours Monday to Friday, 9am-5pm (Standard time zone: UTC/GMT +8 hours).

More Details:213133-77-8 SDS

213133-77-8Relevant articles and documents

Synthesis method of benzimidazole derivative

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Paragraph 0033, (2019/04/10)

The invention discloses a synthesis method of a benzimidazole derivative. The method comprises the following steps: o-phenylenediamine or a derivative thereof and phenylacetic acid or a derivative ofthe phenylacetic acid are used as raw materials, a composite solid catalyst is adopted, and a high-boiling-point organic solvent is taken as a reaction solvent for carrying out a reaction at 100-130 DEG C for 4-8 hours; and distillation, dissolution, neutralization, decoloration and recrystallization are carried out to obtain a benzimidazole derivative product. The method has the advantages that operation is simple, the reaction time is greatly shortened, the product color is good, the yield is high, cost is low, pollution is low, environment friendliness is achieved, and the like, and has a very good industrial production application prospect.

Discovery of benzimidazole derivatives as modulators of mitochondrial function: A potential treatment for Alzheimer's disease

Kim, TaeHun,Yang, Ha Yun,Park, Beoung Gun,Jung, Seo Yun,Park, Jong-Hyun,Park, Ki Duk,Min, Sun-Joon,Tae, Jinsung,Yang, Hyejin,Cho, Suengmok,Cho, Sung Jin,Song, Hyundong,Mook-Jung, Inhee,Lee, Jiyoun,Pae, Ae Nim

, p. 1172 - 1192 (2016/11/23)

In this study, we designed a library of compounds based on the structures of well-known ligands of the 18 kDa translocator protein (TSPO), one of the putative components of the mPTP. We performed diverse mitochondrial functional assays to assess their ability to restore cells from Aβ-induced toxicity in vitro and in vivo. Among tested compounds, compound 25 effectively improved cognitive function in animal models of AD. Given the excellent in vitro and in vivo activity and a favorable pharmacokinetic profile of compound 25, we believe that it can serve as a promising lead compound for a potential treatment option for AD.

BENZIMIDAZOLE DERIVATIVES AS MITOCHONDRIAL FUNCTION MODULATORS

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Paragraph 0217-0218, (2014/05/07)

Provided are a benzimidazole derivative modulating mitochondrial functions and having pharmaceutical activity as a neuro-protective agent, and a pharmaceutical composition including the compound as an active ingredient.

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