213179-53-4

Basic information

• Product Name: (S)-3-(4-Cyano-phenyl)-N-cyclopentyl-N-methyl-2-(5,6,7,8-tetrahydro-naphthalene-2-sulfonylamino)-propionamide
• CAS NO: 213179-53-4
• Molecular Weight: 465.616
• Mol File: 213179-53-4.mol
• Article Data: 2

Chemical Properties

• CAS DataBase Reference: (S)-3-(4-Cyano-phenyl)-N-cyclopentyl-N-methyl-2-(5,6,7,8-tetrahydro-naphthalene-2-sulfonylamino)-propionamide(CAS DataBase Reference)
• NIST Chemistry Reference: (S)-3-(4-Cyano-phenyl)-N-cyclopentyl-N-methyl-2-(5,6,7,8-tetrahydro-naphthalene-2-sulfonylamino)-propionamide(213179-53-4)
• EPA Substance Registry System: (S)-3-(4-Cyano-phenyl)-N-cyclopentyl-N-methyl-2-(5,6,7,8-tetrahydro-naphthalene-2-sulfonylamino)-propionamide(213179-53-4)

Safety Data

• Hazardous Substances Data: 213179-53-4(Hazardous Substances Data)

Upstream product

• 119-64-2 tetralin 
• 61551-49-3 5,6,7,8-tetrahydronaphthalene-2-sulfonyl chloride 
• 184771-40-2 (2S)-2-(N-tert-butoxycarbonyl)-amino-N-cyclopentyl-3-(4-cyanophenyl)-N-methylpropanamide 
• 104-85-8 para-methylbenzonitrile 
• 167479-78-9 (S)-4-Cyanophenylalanine 
• 17201-43-3 4-cyanobenzyl bromide 
• 146664-08-6 N-acetyl-4-cyano-D,L-phenylalanine 
• 131724-45-3 (S)-2-((tert-butoxycarbonyl)amino)-3-(4-cyanophenyl)propanoic acid 

Relevant articles and documents

Fluorobenzamidrazone thrombin inhibitors: Influence of fluorine on enhancing oral absorption

LB30057 (1) is a selective and efficacious oral thrombin inhibitor. Fluorine-substitution on the phenylene ring of the benzamidrazone portion in both compound 1 and its derivatives gave, in many cases, enhanced oral absorption in rats while maintaining the intrinsic potency and selectivity. Compound 2 demonstrated a 3-fold increase in absorption.