21354-40-5

Basic information

• Product Name: 2,2-dimethyl-N-(4-methylphenyl)propanamide
• Synonyms: 2,2-dimethyl-N-(4-methylphenyl)propanamide;N-(4-Methylphenyl)pivalamide;N-(p-Tolyl)pivalamide
• CAS NO: 21354-40-5
• Molecular Formula: C₁₂H₁₇NO
• Molecular Weight: 191.27
• Mol File: 21354-40-5.mol
• Article Data: 33

Chemical Properties

• Boiling Point: 332.3°Cat760mmHg
• Flash Point: 198°C
• Appearance: /
• Density: 1.015g/cm³
• Vapor Pressure: 0.000147mmHg at 25°C
• Refractive Index: 1.541
• CAS DataBase Reference: 2,2-dimethyl-N-(4-methylphenyl)propanamide(CAS DataBase Reference)
• NIST Chemistry Reference: 2,2-dimethyl-N-(4-methylphenyl)propanamide(21354-40-5)
• EPA Substance Registry System: 2,2-dimethyl-N-(4-methylphenyl)propanamide(21354-40-5)

Safety Data

• Hazardous Substances Data: 21354-40-5(Hazardous Substances Data)

Usage

Physical state

White solid substance

Solubility

Soluble in organic solvents

Melting point

Approximately 75-77°C

Usage

Industrial chemical intermediate and building block in the production of various products

Applications

Production of pharmaceuticals for medical applications and synthesis of other organic compounds

Safety precautions

Can be harmful if swallowed or inhaled, may cause skin and eye irritation upon contact

Environmental and health hazards

Potential risks if not handled or disposed of properly

InChI:InChI=1/C12H17NO/c1-9-5-7-10(8-6-9)13-11(14)12(2,3)4/h5-8H,1-4H3,(H,13,14)

Upstream product

• 677-22-5 tert-butylmagnesium chloride 
• 622-58-2 p-Tolylisocyanate 
• 106-49-0 p-toluidine 
• 75-98-9 Trimethylacetic acid 
• 754-10-9 2,2-dimethylpropionamide 
• 106-43-4 para-chlorotoluene 
• 51269-69-3 1-(2',2'-dimethylpropionyl)pyrrolidin-2-one 
• 630-18-2 tert-butyl isocyanide 
• 123726-16-9 bis(4-methylphenyl)iodonium trifluoromethanesulfonate 
• 16002-41-8 N-methyl-N-phenylpivalamide 
• 69120-23-6 (4-Methylphenyl)-pivaloat 
• 815-17-8 trimethylpyruvic acid 
• 24331-71-3 N,N-dimethylpivalamide 
• 57357-20-7 bis(tertbutylcarbonyloxy)iodobenzene 

Downstream Products

• 114995-60-7 2-amino-5-methylphenyl 4-pyridyl ketone 
• 69646-13-5 2,2-Dimethyl-N-(4-methylphenyl)propanimidoylchlorid 
• 87995-50-4 N-(2-bromo-4-methylphenyl)-2,2-dimethylpropanamide 
• 476276-80-9 N-(2-benzoyl-4-methylphenyl)pivalamide 
• 1433186-64-1 N-(4-methyl-2-(trifluoromethyl)phenyl)pivalamide 
• 1378807-56-7 N-(4-methyl-3-(trifluoromethyl)phenyl)pivalamide 
• 205756-33-8 N-(2-iodo-4-methylphenyl)pivalamide 
• 644-08-6 4-Methylbiphenyl 
• 1253778-85-6 N-(4′,5-dimethyl-[1,1′-biphenyl]-2-yl)pivalamide 
• 18931-79-8 N-(2-chloro-4-methylphenyl)pivalamide 
• 1029124-68-2 N-(2-fluoro-4-methylphenyl)pivalamide 
• 1360571-07-8 phenyl N-(4-methylphenyl)pivalimidate 

Relevant articles and documents

Efficient copper catalysts for C[sbnd]H bond arylation under microwave heating: Direct access to multi-substituted pivanilides

We herein describe a parallel comparison between homogeneous and heterogeneous copper catalysts for microwave-assisted direct C[sbnd]H bond arylation. These catalytic systems feature enhanced catalytic activities, unique bulky ligand/base effects, mild co

Metal-free transamidation of benzoylpyrrolidin-2-one and amines under aqueous conditions

N-Acyl lactam amides, such as benzoylpyrrolidin-2-one, benzoylpiperidin-2-one, and benzoylazepan-2-one reacted with amines in the presence of DTBP and TBAI to afford the transamidated products in good yields. The reactions were conducted under aqueous conditions and good functional group tolerance was achieved. Both aliphatic and aromatic primary amines displayed good activity under metal-free conditions. A radical reaction pathway is proposed.

Preparation method of N-aryl amide compound

The invention discloses a preparation method of an N-aryl amide compound, which comprises the following steps: (1) putting diaryliodonium salt and Cu(OAc)2 into a Schlenk tube provided with a magneticstirring rod; (2) sequentially adding DCE, H2O and nitrile by using an injector, sealing the Schlenk tube, and stirring for reaction at 80 DEG C; (3) cooling the obtained solution to room temperature, and performing extraction with EtOAc; and combining organic layers, performing washing with saline water, and performing drying with anhydrous Na2SO4; and (4) removing volatile matters in vacuum, and purifying residues through column chromatography to obtain the N-aryl amide compound. Through a large number of experiments, a substrate with a simple structure is screened, the reaction conditionsare mild, the yield is high, the pollution is small, and the application prospect is wide.