213627-30-6Relevant articles and documents
NOVEL APOPTOSIS SIGNAL-REGULATING KINASE 1 INHIBITORS
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, (2021/01/23)
The present invention relates to inhibitors of apoptosis signal-regulating kinase 1 ("ASK1"), a process for synthesis of the compounds of the present invention, composition comprising the compounds and use of the compounds for inhibition of ASK1.
Discovery and optimization of novel constrained pyrrolopyridone BET family inhibitors
Fidanze, Steven D.,Liu, Dachun,Mantei, Robert A.,Hasvold, Lisa A.,Pratt, John K.,Sheppard, George S.,Wang, Le,Holms, James H.,Dai, Yujia,Aguirre, Ana,Bogdan, Andrew,Dietrich, Justin D.,Marjanovic, Jasmina,Park, Chang H.,Hutchins, Charles W.,Lin, Xiaoyu,Bui, Mai H.,Huang, Xiaoli,Wilcox, Denise,Li, Leiming,Wang, Rongqi,Kovar, Peter,Magoc, Terrance J.,Rajaraman, Ganesh,Albert, Daniel H.,Shen, Yu,Kati, Warren M.,McDaniel, Keith F.
supporting information, p. 1804 - 1810 (2018/04/23)
Novel conformationally constrained BET bromodomain inhibitors have been developed. These inhibitors were optimized in two similar, yet distinct chemical series, the 6-methyl-1H-pyrrolo[2,3-c]pyridin-7(6H)-ones (A) and the 1-methyl-1H-pyrrolo[2,3-c]pyridin
DIHYDRO-PYRROLOPYRIDINONE INHIBITORS
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Paragraph 1266, (2014/09/29)
The present invention provides for compounds of formula (I) wherein R1, R2, R3, R4, and R5 have any of the values defined in the specification, and pharmaceutically acceptable salts thereof, that are useful as agents in the treatment of diseases and conditions, including inflammatory diseases, cancer, and AIDS. Also provided are pharmaceutical compositions comprising one or more compounds of formula (I).