2138-38-7

Basic information

• Product Name: 1-(4-Chlorophenyl)-3-(dimethylamino)-1-propanone
• Synonyms: 1-(4-Chlorophenyl)-3-(dimethylamino)-1-propanone;4'-Chloro-β-(dimethylamino)propiophenone;β-(Dimethylamino)-4'-chloropropiophenone
• CAS NO: 2138-38-7
• Molecular Formula: C₁₁H₁₄ClNO
• Molecular Weight: 211.68796
• Mol File: 2138-38-7.mol
• Article Data: 6

Chemical Properties

• Melting Point: 169-172 °C
• Boiling Point: 310.0±22.0 °C(Predicted)
• Appearance: /
• Density: 1.115±0.06 g/cm3(Predicted)
• PKA: 8.59±0.28(Predicted)
• CAS DataBase Reference: 1-(4-Chlorophenyl)-3-(dimethylamino)-1-propanone(CAS DataBase Reference)
• NIST Chemistry Reference: 1-(4-Chlorophenyl)-3-(dimethylamino)-1-propanone(2138-38-7)
• EPA Substance Registry System: 1-(4-Chlorophenyl)-3-(dimethylamino)-1-propanone(2138-38-7)

Safety Data

• Hazardous Substances Data: 2138-38-7(Hazardous Substances Data)

Usage

General Description

1-(4-Chlorophenyl)-3-(dimethylamino)-1-propanone is a chemical compound with the molecular formula C11H14ClNO. It is a synthetic organic compound with a ketone functional group and a phenyl ring with a chlorine substituent. 1-(4-Chlorophenyl)-3-(dimethylamino)-1-propanone is also known as 4'-Chloro-α,α-dimethylphenylacetone and is commonly used in the production of pharmaceuticals, agrochemicals, and other industrial chemicals. It is also a precursor in the synthesis of various amphetamine and cathinone derivatives, which are used as stimulant drugs. Due to its psychoactive properties, 1-(4-Chlorophenyl)-3-(dimethylamino)-1-propanone is regulated and controlled in many countries to prevent its illicit use and production.

Upstream product

• 1826-67-1 vinyl magnesium bromide 
• 122334-37-6 4-chloro-N-methoxy-N-methylbenzamide 
• 124-40-3 dimethyl amine 
• 33797-51-2 eschenmoser's salt 
• 99-91-2 para-chloroacetophenone 
• 50-00-0 formaldehyd 
• 506-59-2 N,N-dimethylammonium chloride 

Downstream Products

• 477313-11-4 AC 7954 hydrochloride 
• 16254-22-1 1-(4-chlorophenyl)-3-(dimethylamino)propan-1-ol hydrochloride 
• 1236376-24-1 3-(4-chlorophenyl)-3-(2-dimethylaminoethyl)-6-methoxy-isochroman-1-one 
• 1236376-82-1 3-(4-chlorophenyl)-3-(2-dimethylaminoethyl)-3,4-dihydro-2-isopropyl-2H-isoquinolin-1-one hydrochloride 
• 1236376-78-5 3-(4-chlorophenyl)-3-(2-dimethylaminoethyl)-3,4-dihydro-2-methyl-2H-isoquinolin-1-one hydrochloride 
• 1236376-97-8 3-(4-chlorophenyl)-3-(2-dimethylaminoethyl)-6-phenylisochroman-1-one oxalate 
• 1236376-25-2 3-(4-chlorophenyl)-3-(2-dimethylaminoethyl)-6-methoxy-5-methyl-isochroman-1-one 
• 1236376-99-0 2-(4-chlorophenyl)-2-(2-dimethylaminoethyl)-1,2-dihydro-3-oxa-phenanthren-4-one oxalate 
• 1236376-94-5 6-(bis-allylamino)-3-(4-chlorophenyl)-3-(2-dimethylaminoethyl)isochroman-1-one oxalate 
• 653573-43-4 [3-(4-chloro-phenyl)-3-(naphthalen-1-yloxy)-propyl]-dimethyl-amine 

Relevant articles and documents

Synthesis and pharmacological investigation of aralkyl diamine derivatives as potential triple reuptake inhibitors

A series of aralkyl diamine derivatives were designed, synthesized, and evaluated for their triple reuptake inhibitory abilities. Compounds 18c (5-HT, NE, DA, IC50 = 389, 69, 238 nM), 36a (5-HT, NE, DA, IC50 = 378, 477, 247 nM), and

Synthesis and pharmacological evaluation of 3-aryl-3-azolylpropan-1-amines as selective triple serotonin/norepinephrine/dopamine reuptake inhibitors

A series of 3-aryl-3-azolylpropan-1-amines was prepared and screened for its capability of inhibiting monoamine reuptake. Analogs with nanomolar potency, good human in vitro microsomal stability, and low drug-drug interaction potential were described. In

Anticonvulsant activity of semicarbazone derivatives of Mannich bases

A series of semicarbazones of semicarbazide/p-chlorophenyl semicarbazide and Mannich bases of acetophenone/p-chloroacetophenone has been synthesized and their anticonvulsant activity screened against MES and scPTZ test. p-Chlorophenyl semi-carbazone of N,N-dimethylaminopropiophenone has been found to be the most active in all these tests.