21388-77-2

Basic information

• Product Name: 4-(4-methoxybenzyl)phenol
• Synonyms: 4-(4-Methoxybenzyl)phenol; phenol, 4-[(4-methoxyphenyl)methyl]-
• CAS NO: 21388-77-2
• Molecular Formula: C₁₄H₁₄O₂
• Molecular Weight: 214.2598
• Mol File: 21388-77-2.mol
• Article Data: 15

Chemical Properties

• Boiling Point: 363°C at 760 mmHg
• Flash Point: 202.7°C
• Density: 1.12g/cm³
• Vapor Pressure: 8.91E-06mmHg at 25°C
• Refractive Index: 1.585
• CAS DataBase Reference: 4-(4-methoxybenzyl)phenol(CAS DataBase Reference)
• NIST Chemistry Reference: 4-(4-methoxybenzyl)phenol(21388-77-2)
• EPA Substance Registry System: 4-(4-methoxybenzyl)phenol(21388-77-2)

Safety Data

• Hazardous Substances Data: 21388-77-2(Hazardous Substances Data)

Upstream product

• 108-95-2 phenol 
• 104-93-8 p-methylanizole 
• 74189-56-3 4-(tetrahydropyran-2-yloxy)benzaldehyde 
• 123-08-0 4-hydroxy-benzaldehyde 
• 106-41-2 4-bromo-phenol 
• 105-13-5 4-Methoxybenzyl alcohol 
• 106-48-9 4-chloro-phenol 
• 104-21-2 p-methoxybenzyl acetate 
• 39720-27-9 4-acetoxybenzyl chloride 
• 103594-89-4 4-methoxyphenyltitanium triisopropoxide 
• 4397-53-9 p-benzyloxybenzaldehyde 
• 104-92-7 1-bromo-4-methoxy-benzene 
• 936007-02-2 (4-benzyloxyphenyl)(4-methoxyphenyl)methanol 
• 61002-54-8 4-hydroxy-4'-methoxybenzophenone 

Downstream Products

• 1027987-10-5 2-[4-(4-Methoxy-benzyl)-phenoxy]-propionic acid ethyl ester 
• 67807-29-8 4-(4-methoxybenzyl)cyclohexanone 

Relevant articles and documents

Discovery of Salidroside-Derivated Glycoside Analogues as Novel Angiogenesis Agents to Treat Diabetic Hind Limb Ischemia

Therapeutic angiogenesis is a potential therapeutic strategy for hind limb ischemia (HLI); however, currently, there are no small-molecule drugs capable of inducing it at the clinical level. Activating the hypoxia-inducible factor-1 (HIF-1) pathway in skeletal muscle induces the secretion of angiogenic factors and thus is an attractive therapeutic angiogenesis strategy. Using salidroside, a natural glycosidic compound as a lead, we performed a structure-activity relationship (SAR) study for developing a more effective and druggable angiogenesis agent. We found a novel glycoside scaffold compound (C-30) with better efficacy than salidroside in enhancing the accumulation of the HIF-1α protein and stimulating the paracrine functions of skeletal muscle cells. This in turn significantly increased the angiogenic potential of vascular endothelial and smooth muscle cells and, subsequently, induced the formation of mature, functional blood vessels in diabetic and nondiabetic HLI mice. Together, this study offers a novel, promising small-molecule-based therapeutic strategy for treating HLI.

Preparation method of diarylmethane structure compound

The invention discloses a preparation method of a diarylmethane structure compound. The preparation method disclosed by the invention is as shown in a formula I, and a target compound is prepared through reaction of benzyl alcohol and an aryl electrophilic reagent by utilizing a cheap metal nickel catalyst, taking 1, 1 '-bis (diphenylphosphine) ferrocene and 1, 10-phenanthroline as ligands, takingdimethyl oxalate as an additive and taking manganese powder as a reducing agent. The method has the advantages of easily available raw materials, mild reaction conditions, wide reaction substrate, good compatibility of reaction functional groups, unique chemical selectivity and the like. The method not only can be used for preparing the simple diarylmethane compound, but also can be suitable formodifying bioactive molecules with similar structures of raw materials.

Proton-exchanged montmorillonite-mediated reactions of methoxybenzyl esters and ethers

Proton-exchanged montmorillonite (H-mont) was found to be an eco-friendly and cost-effective catalyst for the generation of O-methylated quinone methides (QM) from the corresponding p or o-methoxybenzyl esters and ethers. Nucleophilic trapping of the O-methylated QM with arenes, alcohols, 1,3-dicarbonyl compounds, silyl enol ethers, and allylsilanes has been carried out, respectively, leading to eco-friendly benzylation reactions. Using this protocol, H-mont-mediated deprotection of PMB-protected esters and ethers have been realized for the first time. This work would pave the way for further exploration in O-alkylated QM that are of chemical and biological significance.