21420-61-1

Basic information

• Product Name: Carbamic acid, (diphenylmethyl)-, 1,1-dimethylethyl ester
• CAS NO: 21420-61-1
• Molecular Formula: C18H21NO2
• Molecular Weight: 283.37
• Mol File: 21420-61-1.mol
• Article Data: 15

Chemical Properties

• CAS DataBase Reference: Carbamic acid, (diphenylmethyl)-, 1,1-dimethylethyl ester(CAS DataBase Reference)
• NIST Chemistry Reference: Carbamic acid, (diphenylmethyl)-, 1,1-dimethylethyl ester(21420-61-1)
• EPA Substance Registry System: Carbamic acid, (diphenylmethyl)-, 1,1-dimethylethyl ester(21420-61-1)

Safety Data

• Hazardous Substances Data: 21420-61-1(Hazardous Substances Data)

Upstream product

• 101-81-5 Diphenylmethane 
• 579-55-5 fluorodiphenylmethane 
• 4099-51-8 N-hydroxy-2,2-diphenylacetamide 
• 117-34-0 2,2-diphenylacetic acid 
• 1365942-56-8 N-(4-isopropoxybenzyl)-3-methylpyridin-2-amine 
• 21244-34-8 [4-(propan-2-yloxy)phenyl]methanamine 
• 98-80-6 phenylboronic acid 
• 70720-38-6 benzyl-(3-methyl-2-pyridinyl)amine 
• 100-46-9 benzylamine 
• 5123-13-7 5,5-dimethyl-2-phenyl-1,3,2-dioxaborinane 
• 4406-77-3 2-Phenyl-1,3,2-dioxaborinane 
• 1370412-51-3 tert-butyl benzhydryl(3-methylpyridin-2-yl)carbamate 
• 1370412-53-5 C₁₃H₁₃⁽²⁾HN₂ 
• 24424-99-5 di-tert-butyl dicarbonate 

Downstream Products

• 1609118-08-2 (E)-tert-butyl benzhydryl(buta-1,3-dien-1-yl)carbamate 
• 1292816-64-8 t-butyl N-(diphenylmethyl)-N-[(2-bromophenyl)methyl]carbamate 
• 1292849-61-6 6,7-dihydro-5-phenyl-5H-dibenz[c,e]azepine 
• 1292849-59-2 t-butyl 5-phenyl-5H-dibenz[c,e]azepine-6(7H)-carboxylate 
• 341970-27-2 1-[2-[4-(2-N-tert-butoxycarbonyl-N-diphenylmethylaminomethylphenyl)buta-1,3-diyn-1-yl]phenyl]-6,6-dimethyl-6-silahepta-2,4-diyn-1-ol 
• 341970-43-2 2-[4-(2-N-tert-butoxycarbonyl-N-diphenylmethylaminomethylphenyl)buta-1,3-diyn-1-yl]benzyl alcohol 
• 341970-24-9 2-[4-(2-N-tert-butoxycarbonyl-N-diphenylmethylaminomethylphenyl)buta-1,3-diyn-1-yl]benzaldehyde 
• 341970-36-3 (N-tert-butoxycarbonyl-N-diphenylmethyl)-2-iodobenzylamine 
• 91-00-9 Benzhydrylamine 

Relevant articles and documents

Sulfated tungstate: A highly efficient, recyclable and ecofriendly catalyst for chemoselective N-tert butyloxycarbonylation of amines under the solvent-free conditions

Sulfated tungstate catalyzed an efficient and ecofriendly protocol has been described for the chemoselective N-tert-butyloxycarbonylation of amines under the solvent-free conditions at room temperature. The variety of functionalized aliphatic, aromatic and heteroaromatic amines efficiently undergoes the N-tert-butyloxycarbonylation under the developed protocol. The aminoalcohol, aminophenol, aminoester as well as various chiral amines underwent the chemoselective N-Boc protection under the optimized reaction condition. The rapid reaction rate, mild conditions, very good functional group tolerance, excellent yield, solvent-free, easy recovery products and excellent catalyst recyclability are the advantages of this protocol. This makes the protocol feasible, economical and environmentally benign.

Ultrasound promoted environmentally benign, highly efficient, and chemoselective N-tert-butyloxycarbonylation of amines by reusable sulfated polyborate

The sulfated polyborate catalyzed an efficient and chemoselective N-tert-butyloxycarbonylation of amines under ultrasonic irradiation is developed. A broad substrate scope has been demonstrated for N-Boc protection of various primary/secondary amines. It allows converting several aliphatic/aryl/heteroaryl amines, amino alcohol, aminoester, and chiral amines to their N-Boc-protected derivatives under solvent-free conditions with excellent yields. The protocol has several advantages such as easy catalyst, and product isolation, short reaction time, excellent yields, outstanding chemoselectivity, and catalyst recyclability, among others. This makes the process practicable, economical, and environmentally benign.

One-pot synthesis of primary amines from carboxylic acids through rearrangement of in situ generated hydroxamic acid derivatives

A one-pot synthesis of primary amines from carboxylic acids through a Lossen rearrangement of hydroxamic acid derivatives, which were in situ generated by the reaction of carboxylic acids with O-trimethylsilylhydroxylamine (NH2OTMS) and carbonyl diimidazole (CDI, 1.5 equiv) in dimethyl sulfoxide at room temperature, has been achieved. This one-pot method could be applied to various carboxylic acids such as aromatic, heteroaromatic, aliphatic, and optically active substrates.