214342-63-9

Basic information

• Product Name: 4-BROMO-1-METHYLPYRIDIN-2(1H)-ONE
• Synonyms: 4-BROMO-1-METHYLPYRIDIN-2(1H)-ONE;4-Bromo-1-methylpyridin-2-one;4-BroMo-1-Methylpyridin-2...;4-broMo-1-Methyl-1,2-dihydropyridin-2-one;4-BroMo-1-Methyl-1H-pyridin-2-one;4-Bromo-1-methylpyridin-2-one 4-Bromo-1-methylpyridin-2(1H)-one
• CAS NO: 214342-63-9
• Molecular Formula: C₆H₆BrNO
• Molecular Weight: 188.03
• EINECS: -0
• Mol File: 214342-63-9.mol
• Article Data: 7

Chemical Properties

• Boiling Point: 258℃
• Flash Point: 110℃
• Appearance: /
• Density: 1.664
• Vapor Pressure: 0.014mmHg at 25°C
• Refractive Index: 1.596
• Storage Temp.: Room temperature.
• PKA: -1.45±0.62(Predicted)
• CAS DataBase Reference: 4-BROMO-1-METHYLPYRIDIN-2(1H)-ONE(CAS DataBase Reference)
• NIST Chemistry Reference: 4-BROMO-1-METHYLPYRIDIN-2(1H)-ONE(214342-63-9)
• EPA Substance Registry System: 4-BROMO-1-METHYLPYRIDIN-2(1H)-ONE(214342-63-9)

Safety Data

• Hazardous Substances Data: 214342-63-9(Hazardous Substances Data)

Usage

General Description

4-Bromo-1-methylpyridin-2(1H)-one is a chemical compound with the molecular formula C6H6BrNO. It is a pyridine derivative that contains a bromine atom and a methyl group attached to the pyridine ring. 4-Bromo-1-methylpyridin-2(1H)-one is commonly used as an intermediate in the synthesis of pharmaceuticals and agrochemicals. It has also been studied for its potential use in medicinal chemistry, particularly as a building block in the development of new drugs. Additionally, 4-Bromo-1-methylpyridin-2(1H)-one may have other industrial applications, such as in the production of dyes and other organic compounds. Overall, this chemical has diverse potential applications in various fields, making it an important compound for research and development.

InChI:InChI=1/C6H6BrNO/c1-8-3-2-5(7)4-6(8)9/h2-4H,1H3

Upstream product

• 694-85-9 1-methyl-2-pyridone 
• 36953-37-4 4-bromo-2(1H)-pyridinone 
• 74-88-4 methyl iodide 

Downstream Products

• 1114561-85-1 (S)-6-(2-hydroxy-2-methylpropyl)-3-((S)-1-(4-(1-methyl-2-oxo-1,2-dihydropyridin-4-yl)phenyl)ethyl)-6-phenyl-1,3-oxazinan-2-one 
• 1351413-50-7 (1-methyl-2-oxo-1,2-dihydropyridin-4-yl)boronic acid 
• 1353240-30-8 (2S,5R)-2-hydroxy-8-{(S)-1-[4-(1-methyl-2-oxo-1,2-dihydro-pyridin-4-yl)-phenyl]-ethyl}-6-oxa-8-aza-spiro[4.5]decan-7-one 
• 1193334-33-6 6-cyclopropyl-6-(2-hydroxy-2-methylpropyl)-3-((S)-1-(4-(1-methyl-2-oxo-1,2-dihydropyridin-4-yl)phenyl)ethyl)-1,3-oxazinan-2-one 
• 1114560-94-9 (R)-6-(3-hydroxypropyl)-3-((S)-1-(4-(1-methyl-2-oxo-1,2-dihydropyridin-4-yl)phenyl)ethyl)-6-phenyl-1,3-oxazinan-2-one 
• 1193334-32-5 6-(2-hydroxy-2-methylpropyl)-6-isopropyl-3-((S)-1-(4-(1-methyl-2-oxo-1,2-dihydropyridin-4-yl)phenyl)ethyl)-1,3-oxazinan-2-one 
• 1160790-84-0 1-methyl-4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)pyridin-2(1H)-one 

Relevant articles and documents

Light-induced [2 + 2] cycloadditions for the construction of cyclobutane-fused pyridinyl sulfonyl fluorides

Cyclobutanes are an important class of motifs present in a wide range of natural products and other biologically significant molecules. A photocatalytic [2 + 2] cycloaddition between pyridones or isoquinolones and ethenesulfonyl fluoride was achieved, providing a portal to a class of unique cyclobutane-fused pyridinyl sulfonyl fluorides with quaternary rigid rings (30 examples). Further applications of these novel sulfonyl fluoride molecules in SuFEx click chemistry were also accomplished, providing the corresponding sulfonates and sulphonamides with reasonable yields.

Iridium-Catalysed C-H Borylation of 2-Pyridones; Bisfunctionalisation of CC4

The high regioselectivity associated with the iridium-catalysed borylation of pyridones has been exploited to provide a very direct and efficient entry to C(10) doubly substituted CC4 variants of cytisine. Two approaches have been evaluated based on (i) C-H activation of cytisine (or an N-substituted derivative) followed by N-alkylation (to enable dimer formation) and (ii) direct C-H activation and borylation of CC4 itself. Both approaches provide access to C(10)-functionalized CC4 derivatives, but direct borylation of CC4 allows for a wider range of functional group interconversions to be tolerated.

Heterocyclic derivate tyrosine kinase inhibitor

The invention belongs to the technical field of medicine and particularly relates to a heterocyclic derivate tyrosine kinase inhibitor shown in the formula (I), a pharmaceutically acceptable salt and ester thereof and stereoisomers thereof, wherein Y, W, Q m, L, R1, R2, R3, R4, R5, R6, R7, R7', R8 and R8' are defined in the specification. The invention further relates to a preparation method of the compounds and a pharmaceutical preparation and pharmaceutical compositions containing the compounds, and application of the compounds as the tyrosine kinase inhibitor for preparing medicine for preventing and/or treating cancer diseases caused by EGFR mutation and drug resistance diseases caused by EGFR T790M mutation.