214357-95-6 Usage
General Description
3-Pyrrolidinamine,1-methyl, (3S) is a chemical compound with the molecular formula C5H11N. It is a colorless to pale yellow liquid with a characteristic amine odor. 3-Pyrrolidinamine,1-methyl-,(3S)-(9CI) is also known as N-methyl-3-pyrrolidinamine and is primarily used as an intermediate in the pharmaceutical industry for the synthesis of various drugs and active pharmaceutical ingredients. It is considered to be a chiral compound and exists as a single enantiomer, with the (3S) configuration. This chemical has several potential applications in organic synthesis and drug development due to its versatile reactivity and specific stereochemistry. However, it is important to handle this compound with caution due to its toxic and irritant properties.
Check Digit Verification of cas no
The CAS Registry Mumber 214357-95-6 includes 9 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 6 digits, 2,1,4,3,5 and 7 respectively; the second part has 2 digits, 9 and 5 respectively.
Calculate Digit Verification of CAS Registry Number 214357-95:
(8*2)+(7*1)+(6*4)+(5*3)+(4*5)+(3*7)+(2*9)+(1*5)=126
126 % 10 = 6
So 214357-95-6 is a valid CAS Registry Number.
InChI:InChI=1/C5H12N2/c1-7-3-2-5(6)4-7/h5H,2-4,6H2,1H3/t5-/m0/s1
214357-95-6Relevant articles and documents
Implementation of biocatalysis in continuous flow for the synthesis of small cyclic amines
Hegarty, Eimear,Paradisi, Francesca
, p. 890 - 894 (2020)
Significant progress has been made in establishing transaminases as robust biocatalysts for the green and scalable synthesis of a diverse range of chiral amines.[1] However, very few examples on the amination of small cyclic ketones have been reported.[2] Cyclic ketones are particularly challenging for transaminase enzymes because they do not display the well-defined small and large substituent areas that are characteristic for the biocatalytic mechanism. In this work, we exploited the broad substrate scope of the (S)-selective transaminase from Halomonas elongata (HeWT) to develop an efficient biocatalytic system in continuous flow to generate a range of small cyclic amines which feature very often in pharmaceuticals and agrochemicals.[3] Tetrahydrofuran-3-one and other challenging prochiral ketones were rapidly (5-45 min) transformed to their corresponding amines with excellent molar conversion (94-99%) and moderate to excellent ee.
