214400-72-3Relevant articles and documents
Design, synthesis and in vitro evaluation of novel bivalent S-adenosylmethionine analogues
Joce, Catherine,White, Rebecca,Stockley, Peter G.,Warriner, Stuart,Turnbull, W. Bruce,Nelson, Adam
, p. 278 - 284 (2012/03/11)
In optimal cases, bivalent ligands can bind with exceptionally high affinity to their protein targets. However, designing optimised linkers, that orient the two binding groups perfectly, is challenging, and yet crucial in both fragment-based ligand design