214416-11-2

Basic information

• Product Name: N-(5-methoxy-2-nitrobenzoyl)pyrrolidin-2-methanol
• Synonyms: N-(5-methoxy-2-nitrobenzoyl)pyrrolidin-2-methanol
• CAS NO: 214416-11-2
• Molecular Weight: 280.28
• Mol File: 214416-11-2.mol
• Article Data: 3

Chemical Properties

• CAS DataBase Reference: N-(5-methoxy-2-nitrobenzoyl)pyrrolidin-2-methanol(CAS DataBase Reference)
• NIST Chemistry Reference: N-(5-methoxy-2-nitrobenzoyl)pyrrolidin-2-methanol(214416-11-2)
• EPA Substance Registry System: N-(5-methoxy-2-nitrobenzoyl)pyrrolidin-2-methanol(214416-11-2)

Safety Data

• Hazardous Substances Data: 214416-11-2(Hazardous Substances Data)

Upstream product

• 1882-69-5 5-methoxy-2-nitro-benzoic acid 
• 23356-96-9 (S)-1-Pyrrolidin-2-yl-methanol 
• 63932-00-3 5-methoxy-2-nitrobenzoyl chloride 

Downstream Products

• 191656-11-8 (S)-1-(5-Methoxy-2-nitro-benzoyl)-pyrrolidine-2-carbaldehyde 

Relevant articles and documents

Synthesis of pyrrolobenzodiazepines via the PIFA oxidation of amines. Synthesis of 8-deoxy DC-81

PIFA can be used to introduce the imine moiety into a precursor to the pyrrolobenzodiazepines in 62% yield. This oxidation completes an efficient four-step synthesis of 8-deoxy DC-81.

Pyrrolobenzodiazepines

Compounds of the formulae Ia and Ib: wherein:A is CH2, or a single bond;R2 is selected from: R, OH, OR, CO2H, CO2R, COH, COR, SO2R, CN;R6, R7 and R9 are independently selected from H, R, OH, OR, halo, amino, NHR, nitro, Me3Sn;and R8 is selected from H, R, OH, OR, halo, amino, NHR, nitro, Me3Sn, where R is as defined above, or the compound is a dimer with each monomer being the same or different and being of formula Ia or Ib, where the R8 groups of the monomers form together a bridge having the formula -X-R'-X- linking the monomers, where R' is an alkylene chain containing from 3 to 12 carbon atoms, which chain may be interrupted by one or more hetero-atoms and/or aromatic rings and may contain one or more carbon-carbon double or triple bonds, and each X is independently selected from O, S, or N; except that in a compound of formula Ia when A is a single bond, then R2 is not CH=CH(CONH2) or CH=CH(CONMe2). Other related compounds are also disclosed.