214707-01-4

Basic information

• Product Name: 6-(2,4,6-trifluorophenyl)[1,2,4]triazolo[1,5-a]pyrimidine-5,7-diol
• Synonyms: [1,2,4]Triazolo[1,5-a]pyrimidin-5(1H)-one, 7-hydroxy-6-(2,4,6-trifluorophenyl)-
• CAS NO: 214707-01-4
• Molecular Formula: C₁₁H₅F₃N₄O₂
• Molecular Weight: 282.1782
• EINECS: 606-775-7
• Mol File: 214707-01-4.mol
• Article Data: 2

Chemical Properties

• Density: 1.852g/cm³
• Refractive Index: 1.717
• CAS DataBase Reference: 6-(2,4,6-trifluorophenyl)[1,2,4]triazolo[1,5-a]pyrimidine-5,7-diol(CAS DataBase Reference)
• NIST Chemistry Reference: 6-(2,4,6-trifluorophenyl)[1,2,4]triazolo[1,5-a]pyrimidine-5,7-diol(214707-01-4)
• EPA Substance Registry System: 6-(2,4,6-trifluorophenyl)[1,2,4]triazolo[1,5-a]pyrimidine-5,7-diol(214707-01-4)

Safety Data

• Hazardous Substances Data: 214707-01-4(Hazardous Substances Data)

Upstream product

• 61-82-5 3⁽⁵⁾-amino-1,2,4-triazole 
• 262609-07-4 diethyl (2,4,6-trifluoro-phenyl)-malonate 

Downstream Products

• 214707-02-5 5,7-dichloro-6-(2,4,6-trifluorophenyl)-[1,2,4]triazolo[1,5-a]pyrimidine 
• 849550-72-7 5-bromo-6-(2,4,6-trifluorophenyl)-N-[(1S)-2,2,2-trifluoro-1-methylethyl][1,2,4]triazolo[1,5-a]pyrimidin-7-amine 
• 849550-71-6 5,7-dibromo-6-(2,4,6-trifluorophenyl)[1,2,4]triazolo[1,5-a]pyrimidine 

Relevant articles and documents

Method for production of aryl-substituted annelated pyrimidines

The present invention relates to a process for preparing aryl-substituted fused pyrimidines of the general formula (I) in which L1 to L5 are H, halogen, CN, NO2, C1-C4-alkyl, C1-C4-haloalkyl, C1-C4-alkoxy, C1-C4-haloalkoxy etc.; Y1 to Y3 are C—RY or N; RY is H or optionally substituted C1-C4-alkyl or two adjacent RY together form a ring; X is OH, Cl or Br; which comprises (i) the reaction of a 2-phenylmalonate with a compound (III) or a tautomer thereof, in the presence of a suitable base, where the alcohol, released during the reaction, of the formula R—OH is continuously removed from the reaction mixture under reduced pressure; giving a compound of the formula (I) or a salt thereof in which X is OH, and, if X in the compounds of the general formula (I) is chlorine or bromine, (ii) the reaction of the compounds of the formula (I) obtained in step (i) or the salts with a halogenating agent.