21477-59-8

Basic information

• Product Name: 4-(cyclohexylamino)-4-oxobut-2-enoic acid
• CAS NO: 21477-59-8
• Molecular Formula: C₁₀H₁₅NO₃
• Molecular Weight: 197.231
• Mol File: 21477-59-8.mol
• Article Data: 9

Chemical Properties

• Boiling Point: 430.9°C at 760 mmHg
• Flash Point: 214.4°C
• Density: 1.16g/cm³
• Vapor Pressure: 1.25E-08mmHg at 25°C
• Refractive Index: 1.523
• CAS DataBase Reference: 4-(cyclohexylamino)-4-oxobut-2-enoic acid(CAS DataBase Reference)
• NIST Chemistry Reference: 4-(cyclohexylamino)-4-oxobut-2-enoic acid(21477-59-8)
• EPA Substance Registry System: 4-(cyclohexylamino)-4-oxobut-2-enoic acid(21477-59-8)

Safety Data

• Hazardous Substances Data: 21477-59-8(Hazardous Substances Data)

Usage

General Description

4-(cyclohexylamino)-4-oxobut-2-enoic acid is a chemical compound with the molecular formula C12H17NO3. It belongs to the class of compounds known as beta-amino acids and derivatives. 4-(cyclohexylamino)-4-oxobut-2-enoic acid is a derivative of butenoic acid and contains a cyclohexylamino group. It is a white solid at room temperature and is soluble in water. 4-(cyclohexylamino)-4-oxobut-2-enoic acid is commonly used in the pharmaceutical industry for its potential biological and therapeutic properties, including anti-inflammatory and analgesic effects. It is currently being studied for its potential applications in treating various medical conditions.

Upstream product

• 108-31-6 maleic anhydride 
• 108-91-8 cyclohexylamine 
• 110-16-7 maleic acid 

Downstream Products

• 1631-25-0 N-cyclohexylmaleimide 
• 1224255-39-3 (Z)-4-(4-((4-chlorophenyl)(phenyl)methyl)piperazin-1-yl)-N-cyclohexyl-4-oxobut-2-enamide 
• 1224255-52-0 (Z)-4-(4-(bis(4-fluorophenyl)methyl)piperazin-1-yl)-N-cyclohexyl-4-oxobut-2-enamide 

Relevant articles and documents

Lewis acid–catalyzed green synthesis and biological studies of pyrrolo[3,4-c]pyrazoles in aqueous medium

An environmentally benign approach in aqueous medium by means of Lewis acid catalyst affords a wide spectrum of pyrazoline derivatives in satisfactory yields. [3+2] cycloaddition reactions of substituted azomethine-N-imines to maleimide in aqueous medium at relatively high concentrations of Lewis acid catalyst have emerged as an environment friendly alternative to conventional solvents. Promising catalytic activity has been revealed by Lewis acid like Cu (NO3)2 in aqueous medium. The obvious features of this synthetic protocol were short reaction time, high efficiency, less hazardous synthesis by benign solvent, catalysis, modest workup, and a clean reaction methodology.

Synthesis and Evaluation of Novel 5-cyclohexyl-2-(4″-substitutedphenyl)-3-(2″-substitutedphenyl)4H-2,3,3a,5,6,6a-hexahydropyrrolo[3,4-d]isoxazole-4,6-dione Derivatives for Their In Vitro Antioxidant and Antibacterial Activities

1,3-Dipolar cycloaddition reactions of N-cyclohexyl maleimide (1) with azomethine N-oxide (2) have afforded novel isoxazolidine (3) in excellent yield. Their structures have been characterized from their IR,1H-NMR,13C-NMR,1H,1H-COSY, MS(ESI), and elemental analysis techniques. In vitro antibacterial activity of the synthesized compounds were investigated against a representative panel of pathogenic strains specifically two Gram-positive bacteria (Staphylococcus aureus and Streptococcus pyogenes) and two Gram-negative bacteria (Pseudomonas aeruginosa and Escherichia coli) using agar-well diffusion assay. Some of the compounds (3a, 3k, 3n, and 3o) exhibited promising antibacterial activities. All the synthesized compounds have also been screened for their antioxidant activities and were found to be significantly active.

Synthesis and bradykinin inhibitory activity of novel non-peptide compounds, and evaluation of in vivo analgesic activity

A series of novel non-peptide diamide compounds was synthesized and evaluated as antibradykinin agents by utilizing guinea-pig ileum smooth muscle. Among the final compounds, (Z)-4-(4-(bis(4-fluorophenyl)methyl)piperazin-1-yl)-4-oxo-N-(4-phenylbutan-2-yl)