2148-55-2

Basic information

• Product Name: 4,5-Dichloroquinazoline
• Synonyms: 4,5-Dichloroquinazoline
• CAS NO: 2148-55-2
• Molecular Formula: C₈H₄Cl₂N₂
• Molecular Weight: 199.03916
• Product Categories: Halides;Heterocycles
• Mol File: 2148-55-2.mol
• Article Data: 4

Chemical Properties

• Melting Point: 131.5-133 °C
• Boiling Point: 317.6 °C at 760 mmHg
• Flash Point: 175.3 °C
• Appearance: /
• Density: 1.486 g/cm³
• Vapor Pressure: 0.00071mmHg at 25°C
• Refractive Index: 1.67
• Storage Temp.: under inert gas (nitrogen or Argon) at 2-8°C
• PKA: 0.12±0.30(Predicted)
• CAS DataBase Reference: 4,5-Dichloroquinazoline(CAS DataBase Reference)
• NIST Chemistry Reference: 4,5-Dichloroquinazoline(2148-55-2)
• EPA Substance Registry System: 4,5-Dichloroquinazoline(2148-55-2)

Safety Data

• Hazardous Substances Data: 2148-55-2(Hazardous Substances Data)

Usage

General Description

4,5-Dichloroquinazoline is a chemical compound with the molecular formula C8H4Cl2N2. It is a quinazoline derivative, which is a class of compounds known for their pharmaceutical and biological activity. The presence of two chlorine atoms on the quinazoline structure gives 4,5-Dichloroquinazoline unique chemical properties, making it suitable for various applications in the pharmaceutical and agrochemical industries. 4,5-Dichloroquinazoline has been studied for its potential as an anti-cancer agent and has also been investigated for its use in the synthesis of various pharmaceutical compounds. Additionally, 4,5-Dichloroquinazoline has been found to exhibit pesticidal properties, making it a potential candidate for the development of new agricultural chemicals. Overall, the chemical 4,5-Dichloroquinazoline shows promise for a range of industrial and biological applications.

InChI:InChI=1/C8H4Cl2N2/c9-5-2-1-3-6-7(5)8(10)12-4-11-6/h1-4H

Upstream product

• 2148-56-3 2-chloro-6-aminobenzoic acid 
• 60233-66-1 5-chloroquinazoline-4(3H)-one 

Relevant articles and documents

Discovery of quinazolinyl-containing benzamides derivatives as novel HDAC1 inhibitors with in vitro and in vivo antitumor activities

A series of quinazolinyl-containing benzamide derivatives were designed, synthesized and evaluated for their in vitro histone deacetylase 1 (HDAC1) inhibitory activities. Compounds 11a surpassed the known class I selective HDAC inhibitor MS-275 in both HDAC1 enzymatic inhibitory activity and cellular anti-proliferative activity against a selected set of cancer cell types (Hut78, K562, Hep3B and HCT116 cells) with no observed effects on human normal cells. In particular, compound 11a inhibited HDAC1 over the other tested HDACs isoforms (HDAC2, HDAC6 and HDAC8) with acceptable safety profiles. Moreover, compound 11a displayed favorable oral pharmacokinetic properties and showed significant antitumor activity in the A549 tumor xenograft model in vivo.

4-aminoquinazoline grafted acrylamide compounds, preparation method and application thereof

The invention relates to 4-aminoquinazoline grafted acrylamide compounds, a preparation method and application thereof. The compounds have a structure shown as general formula (I) in the specification. According to the invention, a quinazoline compound is adopted as the basis, and acrylamido is introduced into the system to synthesize a series of acrylamido-containing substituted 4-aminoquinazoline compounds, and the compounds have a good inhibiting effect on plant pathogenic bacteria, and have good inhibiting effect on pathogenic bacteria directed at Xanthomonas oryzae pv. Oryzae, Xanthomonasaxonopodis pv. Citri, etc.