215162-34-8

Basic information

• Product Name: 1,3,5-Tris(carboxyMethoxy)benzene
• Synonyms: 1,3,5-Tris(carboxyMethoxy)benzene;2,2',2''-(Benzene-1,3,5-triyltris(oxy))triacetic acid
• CAS NO: 215162-34-8
• Molecular Formula: C₁₂H₁₂O₉
• Molecular Weight: 300.21828
• Mol File: 215162-34-8.mol
• Article Data: 7

Chemical Properties

• Melting Point: 285-287 °C(Solv: water (7732-18-5))
• Boiling Point: 598.0±45.0 °C(Predicted)
• Appearance: /
• Density: 1.540±0.06 g/cm3(Predicted)
• Storage Temp.: 2-8°C
• PKA: 2.60±0.10(Predicted)
• CAS DataBase Reference: 1,3,5-Tris(carboxyMethoxy)benzene(CAS DataBase Reference)
• NIST Chemistry Reference: 1,3,5-Tris(carboxyMethoxy)benzene(215162-34-8)
• EPA Substance Registry System: 1,3,5-Tris(carboxyMethoxy)benzene(215162-34-8)

Safety Data

• Hazardous Substances Data: 215162-34-8(Hazardous Substances Data)

Usage

General Description

1,3,5-Tris(carboxyMethoxy)benzene, also known as TMB, is a chemical compound with the molecular formula C12H9O9. It is a white crystalline solid that is soluble in water and ethanol. TMB is often used as a building block for various organic compounds and can also be used as a precursor in the production of pharmaceuticals and agrochemicals. Its unique molecular structure and properties make it an important reagent in chemical synthesis and research. TMB is considered to be relatively low in toxicity and is not known to pose significant health risks when handled and used properly.

Upstream product

• 108-73-6 3,5-dihydroxyphenol 
• 478812-59-8 triethyl 2,2',2''-[benzene-1,3,5-triyltris(oxy)]triacetate 
• 314241-45-7 (3,5-bis-methoxycarbonyl-methoxy-phenoxy)acetic acid methyl ester 
• 79-11-8 chloroacetic acid 
• 105-36-2 ethyl bromoacetate 

Downstream Products

• 616873-79-1 1,3,5-benzenetrioxytriacetic acid tri-(3-tert-butyl-5-formyl-4-hydroxy-phenyl)ester 
• 942221-91-2 (3,5-bis-chlorocarbonylmethoxy-phenoxy)-acetyl chloride 

Relevant articles and documents

Synthesis and crystal structure of Mn(II) and Zn(II) complexes with 1,3,5-tris(carboxymethoxyl)benzene ligand

Two complexes (H2bipy)[M2(TB)2(H 2O)8]?5H2O (M = Mn 1, Zn 2) (bipy = 4,4′-bipyridine, H3TB = 1,3,5-tris(carboxymethoxyl)benzene) were synthesized by the reaction of the correspon

Microwave (MW), ultrasound (US) and combined synergic MW-US strategies for rapid functionalization of pharmaceutical use phenols

Increasingly stringent regulations aimed at protection of the natural environment have stimulated the search for new synthetic methodologies in organic and medicinal chemistry having no or minimum harmful effect. An interesting approach is the use of alternative activation factors, microwaves (MW) or ultrasounds (US) and also their cross-combination, which has been tested in the fast and efficient creation of new structures. At present, an easy and green hybrid strategy (“Lego” chemistry) is generally recommended for the design of new substances from different chemistry building blocks. Often, selected biologically active components with specific chemical reactivities are integrated by a suitably designed homo- or heterodifunctional linker that modifies the functionality of the starting structure, allowing easy covalent linkage to another molecule. In this study, a fast introduction of heterodifunctional halogenoacidic linker to selected mono-, di- and triphenolic active substances, allowing their functionalization, was investigated. Nucleophilic substitution reaction was chosen to produce final ethers with the reactive carboxylic group from phenols. The functionalization was performed using various green factors initiating and supporting the chemical reactions (MW, US, MW-US). The benefits of the three green supporting methods and different conditions of reactions were analyzed and compared with the results of the reaction performed by conventional methods.

Highly enantioselective resolution of terminal epoxides with cross-linked polymeric salen-Co(III) complexes

Crosslinked polymeric salen-Co(III) complexes derived from a novel dialdehyde and a trialdehyde were synthesized and employed in the hydrolytic kinetic resolution (HKR) of terminal epoxides. Up to 99% ee were obtained with only 0.16-0.02 mol% of catalyst (based on catalytic unit).