215168-93-7

Basic information

• Product Name: 3-(3,4-dimethoxy-phenyl)-1-[3-(3-{3-[3-(3,4-dimethoxy-phenyl)-propionyl]-phenoxy}-2-hydroxy-propoxy)-phenyl]-propan-1-one
• Synonyms: 3-(3,4-dimethoxy-phenyl)-1-[3-(3-{3-[3-(3,4-dimethoxy-phenyl)-propionyl]-phenoxy}-2-hydroxy-propoxy)-phenyl]-propan-1-one
• CAS NO: 215168-93-7
• Molecular Weight: 628.719
• Mol File: 215168-93-7.mol
• Article Data: 1

Chemical Properties

• CAS DataBase Reference: 3-(3,4-dimethoxy-phenyl)-1-[3-(3-{3-[3-(3,4-dimethoxy-phenyl)-propionyl]-phenoxy}-2-hydroxy-propoxy)-phenyl]-propan-1-one(CAS DataBase Reference)
• NIST Chemistry Reference: 3-(3,4-dimethoxy-phenyl)-1-[3-(3-{3-[3-(3,4-dimethoxy-phenyl)-propionyl]-phenoxy}-2-hydroxy-propoxy)-phenyl]-propan-1-one(215168-93-7)
• EPA Substance Registry System: 3-(3,4-dimethoxy-phenyl)-1-[3-(3-{3-[3-(3,4-dimethoxy-phenyl)-propionyl]-phenoxy}-2-hydroxy-propoxy)-phenyl]-propan-1-one(215168-93-7)

Safety Data

• Hazardous Substances Data: 215168-93-7(Hazardous Substances Data)

Upstream product

• 3132-64-7 1,2-Epoxy-3-bromopropane 
• 178445-83-5 3-(3,4-dimethoxyphenyl)-1-(3-hydroxyphenyl)-1-propanone 
• 178445-80-2 (E)-1-(3,4-dimethoxyphenyl)-3-(3-hydroxyphenyl)prop-2-en-1-one 
• 120-14-9 3,4-dimethoxy-benzaldehyde 
• 121-71-1 3-Hydroxyacetophenone 

Downstream Products

• 215168-94-8 1-[3-(2-(tert-butyl-dimethyl-silanyloxy)-3-{3-[3-(3,4-dimethoxy-phenyl)-propionyl]-phenoxy}-propoxy)-phenyl]-3-(3,4-dimethoxy-phenyl)-propan-1-one 
• 215169-02-1 C₆₉H₉₆N₂O₁₅Si 
• 215168-95-9 (R,R)-[2-[3-[3-(3,4-dimethoxyphenyl)-1-hydroxypropyl]phenoxy]-1-[3-[3-(3,4-dimethoxyphenyl)-1-hydroxypropyl]phenoxymethyl]ethoxy]dimethyl-(1,1-dimethylethyl)silane 

Relevant articles and documents

Synthesis and activity of bivalent FKBP12 ligands for the regulated dimerization of proteins

The total synthesis and in vitro activities of a series of chemical inducers of dimerization (CIDs) is described. The use of small-molecule CIDs to control the dimerization of engineered FKBP12-containing fusion proteins has been demonstrated to have broad utility in biological research as well as potential medical applications in gene and cell therapies. The facility and flexibility of preparation make this new class of wholly synthetic compounds exceptionally versatile tools for the study of intracellular signaling events mediated by protein-protein interactions or protein localization. While some congeners possess potency comparable to or better than the first generation natural product-derived CID, FK1012, structure-activity relationships are complex and underscore the need for application-specific compound optimizations. Copyright (C) 1998 Elsevier Science Ltd.