21560-29-2

Basic information

• Product Name: 6,7-DiMethoxy-1-chloroisoquinoline
• Synonyms: 6,7-DiMethoxy-1-chloroisoquinoline;1-chloro-6,7-diMethoxyisoquinoline
• CAS NO: 21560-29-2
• Molecular Formula: C₁₁H₁₀ClNO₂
• Molecular Weight: 223.6556
• Mol File: 21560-29-2.mol
• Article Data: 5

Chemical Properties

• Melting Point: 155-160 °C
• Boiling Point: 355.1±37.0 °C(Predicted)
• Appearance: /
• Density: 1.265±0.06 g/cm3(Predicted)
• Storage Temp.: under inert gas (nitrogen or Argon) at 2-8°C
• PKA: 2.92±0.40(Predicted)
• CAS DataBase Reference: 6,7-DiMethoxy-1-chloroisoquinoline(CAS DataBase Reference)
• NIST Chemistry Reference: 6,7-DiMethoxy-1-chloroisoquinoline(21560-29-2)
• EPA Substance Registry System: 6,7-DiMethoxy-1-chloroisoquinoline(21560-29-2)

Safety Data

• Hazardous Substances Data: 21560-29-2(Hazardous Substances Data)

Usage

General Description

6,7-DiMethoxy-1-chloroisoquinoline is a chemical compound with the molecular formula C11H10ClNO2. It is a derivative of isoquinoline and contains two methoxy groups and a chlorine atom attached to the isoquinoline ring. 6,7-DiMethoxy-1-chloroisoquinoline has potential applications in the pharmaceutical industry, particularly in the development of new drugs and medicinal compounds. It may also have uses in organic synthesis and chemical research. However, its specific properties and potential uses have not been extensively studied, and further research is needed to fully understand its characteristics and potential applications.

Upstream product

• 16101-63-6 6,7-dimethoxy-isoquinolin-1-ol 
• 15248-39-2 6,7-dimethoxyisoquinoline 
• 2316-26-9 3,4-dimethoxycinnamic acid 
• 120-20-7 2-(3,4-dimethoxyphenyl)-ethylamine 
• 16101-63-6 6,7-dimethoxyisoquinoline-1(2H)-one 
• 40788-74-7 6,7-dimethoxyisoquinoline 2-oxide 
• 17889-63-3 N-<2-(3,4-Dimethoxyphenyl)ethyl>carbamidsaeureethylester 
• 24186-43-4 (E)-3-(3,4-Dimethoxy-phenyl)-acryloyl azide 
• 24186-50-3 4-((E)-2-Isocyanato-vinyl)-1,2-dimethoxy-benzene 
• 120-14-9 3,4-dimethoxy-benzaldehyde 
• 493-49-2 6,7-dimethoxy-3,4-dihydro-2H-isoquinolin-1-one 

Downstream Products

• 15547-50-9 6,7-dimethoxy-1-(3,4-dimethoxyphenyl)-isoquinoline 
• 85932-64-5 1-<2-(4-clorophenyl)ethyl>-6,7-dimethoxyisoquinoline 
• 1613479-64-3 1-(4-fluorophenoxy)-6,7-dimethoxyisoquinoline 
• 1613479-58-5 C₁₇H₁₃F₂NO₃ 

Relevant articles and documents

NHC-Organocatalyzed CAr?O Bond Cleavage: Mild Access to 2-Hydroxybenzophenones

A Truce–Smiles rearrangement of acyl-anion equivalents generated by N-heterocyclic carbene (NHC) catalysis has been achieved. The developed method includes CAr?O, CAr?S, or CAr?N bond cleavage for the formation of a CAr?C bond and enables access to 2-hydroxybenzophenones, an important structural motif that is present in several bioactive natural products. By utilizing this procedure, the alkaloid taxilamine was synthesized in three steps. DFT calculations and control experiments support a classical SNAr mechanism with a catalyst-bound Meisenheimer-type intermediate. The method features mild reaction conditions, excellent functional-group tolerance, and a broad substrate scope, including various classes of (hetero)arenes.

Discovery of a 4-aryloxy-1H-pyrrolo[3,2-c]pyridine and a 1-aryloxyisoquinoline series of TRPA1 antagonists

A series of TRPA1 antagonists is described having a 4-aryloxy-1H-pyrrolo[3, 2-c]pyridine or a 1-aryloxyisoquinoline scaffold. These compounds have high ligand efficiency and favorable physical properties and may thus serve as scaffolds for further optimization.

NICKEL-PHOSPHINE COMPLEX-CATALYZED GRIGNARD COUPLING-II; GRIGNARD COUPLING OF HETEROCYCLIC COMPOUNDS

A general, versatile method for alkylation and arylation of haloheterocyclic compounds is reported.In the presence of a catalytic quantity of , where dppp stands for Ph2P(CH2)3PPh2, bromothiophenes, halopyridines, haloquinoline, and haloisoquinolines reacted with alkyl and aryl Grignard reagents at room temperature or at ether refluxing temperature to give the cross-coupling products.The coupling reactions has been applied to the synthesis of isoquinoline alkaloids.Reactivities of 2-thienyl and 2-pyridyl Grignard reagents have also been examined.