21568-72-9Relevant articles and documents
A scalable synthesis of the antidepressant agomelatine by a tandem allylic chlorination-isomerization process
Stathakis, Christos I.,Neokosmidis, Efstratios,Koftis, Theocharis V.
, p. 6376 - 6379 (2016/02/18)
A concise, scalable, and industrially applicable process for the synthesis of the antidepressant agomelatine is described. The process relies on a tandem allylic chlorination-isomerization sequence, on a tetralone-derived allyl carbinol, as the key transformation. The target compound is obtained in five steps from commercially available 7-methoxy-1-tetralone, in 52.3 % overall yield after final recrystallization. A tandem allylic rearrangement-isomerization sequence on a tetralone-derived allyl carbinol was applied for the preparation of agomelatine, a high-potential antidepressant agent with improved pharmacokinetic profile. The active pharmaceutical ingredient (API) was obtained in 52.3 % overall yield and excellent purity (> 99.5 %) by a simple process amenable to industrial-scale applications.
